Evidence map›Paper›PMID 32862276›Full record

ArticleGeroScience2021

The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging.

Vienna E Brunt, Thomas J LaRocca, Amy E Bazzoni, Zachary J Sapinsley, Jill Miyamoto-Ditmon, Rachel A Gioscia-Ryan, Andrew P Neilson, Christopher D Link, Douglas R Seals

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 3 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 3 syntheses or guidelines pooled it, 176 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Gut microbes · 2026
    Review
  6. The microbiota-proteostasis axis: implications in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Urinary metabolites and fatigue in a population-based metabolomics study: an exploratory analysis.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  13. Review
  14. Involvement of trimethylamine N-oxide in major depressive disorder via astrocytic d-Serine dysregulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Relationship BetweenCardiology research and practice · 2026
    Article

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Vienna E BruntDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant St, 354 UCB, Boulder, CO, 80309, USA.ORCID https://orcid.org/0000-0002-1941-7936
Thomas J LaRoccaDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant St, 354 UCB, Boulder, CO, 80309, USA.ORCID https://orcid.org/0000-0002-2393-7299
Amy E BazzoniDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant St, 354 UCB, Boulder, CO, 80309, USA.
Zachary J SapinsleyDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant St, 354 UCB, Boulder, CO, 80309, USA.
Jill Miyamoto-DitmonDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant St, 354 UCB, Boulder, CO, 80309, USA.
Rachel A Gioscia-RyanDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant St, 354 UCB, Boulder, CO, 80309, USA.ORCID https://orcid.org/0000-0001-5372-2152
Andrew P NeilsonDepartment of Food Science and Technology, Virginia Tech, Blacksburg, VA, USA.ORCID https://orcid.org/0000-0001-5497-663X
Christopher D LinkDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant St, 354 UCB, Boulder, CO, 80309, USA.ORCID https://orcid.org/0000-0003-2271-7697
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant St, 354 UCB, Boulder, CO, 80309, USA. seals@colorado.edu.ORCID https://orcid.org/0000-0002-8900-9954
University of Colorado Boulder · USNorth Carolina State University · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
TDP-43, RNA Metabolism, and ALS/FTD PathologyR01NS063964 · NINDS · UNIVERSITY OF COLORADO · PI LINK, CHRISTOPHER D. · 2009 to 2019
$3.5M
Translational Studies of Age-Associated Arterial Dysfunction, Western Diet and Aerobic Exercise: Role of the Gut MicrobiomeR01HL134887 · NHLBI · UNIVERSITY OF COLORADO · PI SEALS, DOUGLAS R · 2017 to 2020
$3.1M
Translational studies of gut-derived trimethylamine N-oxide: a target for prevention and treatment of age-associated vascular endothelial dysfunctionF32HL140875 · NHLBI · UNIVERSITY OF COLORADO · PI BRUNT, VIENNA E · 2018 to 2019
$89k
NCATS NIH HHS UL1 TR002535NHLBI NIH HHS F32 HL140875NHLBI NIH HHS R01 HL134887NINDS NIH HHS R01 NS063964
6 · The paper itself

Abstract

Aging is associated with declines in cognitive performance, which are mediated in part by neuroinflammation, characterized by astrocyte activation and higher levels of pro-inflammatory cytokines; however, the upstream drivers are unknown. We investigated the potential role of the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO) in modulating neuroinflammation and cognitive function with aging. Study 1: In middle-aged and older humans (65 ± 7 years), plasma TMAO levels were inversely related to performance on NIH Toolbox Cognition Battery tests of memory and fluid cognition (both r

Indexed as

Gastrointestinal MicrobiomeAgingAnimalsCognitionMethylaminesMiceMethylaminestrimethyloxamineAstrocyte activationBrainCognitive impairmentInflammationMemory

Identifiers

PMID32862276
PMCPMC8050157
OpenAlexW3082564026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.