ArticleDiabetologia2020
Higher BMI is associated with smaller regional brain volume in older adults with type 2 diabetes.
Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- Effects of Tai Chi on Cognitive Function in Older Adults With Type 2 Diabetes Mellitus: Randomized Controlled Trial Using Wearable Devices in a Mobile Health Model.Journal of medical Internet research · 2025Trial
- Effects of Tai Chi Chuan on Cognitive Function in Adults 60 Years or Older With Type 2 Diabetes and Mild Cognitive Impairment in China: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Cardiometabolic Risk Factors and Domain-Specific Cognitive Function in Prediabetes and Type 2 Diabetes.Medical sciences (Basel, Switzerland) · 2026Article
- Body Mass Index and Dietary Self-Regulation Are Associated with Attenuated Error Monitoring in Young Adults.Nutrients · 2026Article
- Association of Long-Term Trajectories in Obesity Indices With Neuroimaging Metrics and Cognition: A Population-Based Study.Diabetes, obesity & metabolism · 2026Article
- A body shape index trajectories and cognitive function among older hypertensive patients: a national cohort study.Archives of public health = Archives belges de sante publique · 2026Article
- Atraric Acid Ameliorates Neurological Dysfunction in High-Fat Diet-Fed Mice by Activating Autophagy to Alleviate Brain Oxidative Stress and Neuroinflammation.Molecular neurobiology · 2025Article
- Obesity and brain volumes: mediation by cardiometabolic and inflammatory measures.Stroke and vascular neurology · 2025Article
- Effects of Digital Neurohabilitation on Attention and Memory in Patients with a Diagnosis of Pediatric Obesity: Case Series.Brain sciences · 2025Article
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- The Influence of Birth Weight, Socio-Economic Status, and Adult Health on Brain Volumes during Ageing.Neuroepidemiology · 2025Article
- Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging.Psychophysiology · 2023Article
- The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review.Frontiers in medicine · 2023Review
- Recent Updates on Associations among Various Obesity Metrics and Cognitive Impairment: from Body Mass Index to Sarcopenic Obesity.Journal of obesity & metabolic syndrome · 2022Review
- Stability in BMI over time is associated with a better cognitive trajectory in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Dietary Supplement ofDrug design, development and therapy · 2022Article
- Altered cortical thickness, degree centrality, and functional connectivity in middle-age type 2 diabetes mellitus.Frontiers in neurology · 2022Article
- Obesity is associated with greater cognitive function in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
aims/hypothesisThere are established relationships between adiposity (obesity) and higher dementia risk, faster cognitive decline and associated neural injury. Type 2 diabetes is strongly linked to greater adiposity and has been consistently associated with neural injury and poor cognitive outcomes. However, although obesity is a major cause of type 2 diabetes, there is limited evidence on the association of adiposity with brain atrophy among individuals with type 2 diabetes.
methodsWe examined the association of BMI (a measure of adiposity), and of long-term trajectories of BMI (three empirically identified groups of trajectories-'normal', 'overweight' and 'obese'-using SAS macro PROC TRAJ), with regional brain volume, in a sample of older individuals (aged 64-84) with type 2 diabetes participating in the Israel Diabetes and Cognitive Decline Study (n = 198).
resultsUsing linear regression, we found that greater BMI was associated with smaller volumes of the inferior frontal gyrus (IFG) (r = -0.25, p = 0.001) and the middle temporal gyrus (r = -0.19; p = 0.010) after adjusting for sociodemographic covariates and total intracranial volume. In addition, there were significant differences between BMI trajectory groups in IFG volume (F = 4.34, p = 0.014), such that a long-term trajectory of obesity was associated with a smaller volume. Additional adjustment for cardiovascular and diabetes-related potential confounders did not substantively alter the results. There were no associations of adiposity with superior frontal gyrus, middle frontal gyrus or total grey matter volumes. CONCLUSIONS/
interpretationIn older adults with type 2 diabetes, long-term adiposity may have a detrimental impact on volume of brain regions relevant to cognitive functioning. Further studies to identify the underlying mechanisms are warranted. Graphical abstract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.