ArticleEuropean journal of applied physiology2020
Blunted cardiac output response to exercise in adolescents born preterm.
Article in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Lung volumes, gas transfer and oscillometry after preterm birth: systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Physiological responses to exercise in survivors of preterm birth: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Impaired lung function and associated risk factors in children born prematurely: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Influence of Preterm Birth and Low Birthweight on Physical Fitness: A Systematic Review, Meta-Analysis, and Meta-Regression.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Impact of preterm birth on muscle mass and function: a systematic review and meta-analysis.European journal of pediatrics · 2024Pooled it
- The Effect of Preterm Birth on Maximal Aerobic Exercise Capacity and Lung Function in Healthy Adults: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Aerobic Exercise Training Response in Preterm-Born Young Adults with Elevated Blood Pressure and Stage 1 Hypertension: A Randomized Clinical Trial.American journal of respiratory and critical care medicine · 2023Trial
- From Neonatal History to Adult Cardiovascular Risk: Preterm Birth as a Lifelong Risk Enhancer.Medical sciences (Basel, Switzerland) · 2026Review
- Central and Peripheral Mechanisms of Low Exercise Capacity in Prematurely Born Adults.Comprehensive physiology · 2025Article
- Smaller Left Ventricular Size But Preserved Function in Adolescents and Adults Born Preterm.Journal of the American Heart Association · 2024Article
- Elevated pulmonary capillary wedge pressure, higher blood pressure, and lower cardiac index in infants with bronchopulmonary dysplasia.International journal of cardiology · 2024Article
- Exercise Capacity in Very Low Birth Weight Adults: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Prematurity blunts protein synthesis in skeletal muscle independently of body weight in neonatal pigs.Pediatric research · 2023Article
- Impact of premature birth on cardiopulmonary function in later life.European journal of pediatrics · 2023Article
- Understanding the preterm human heart: What do we know so far?Anatomical record (Hoboken, N.J. : 2007) · 2022Review
- Exercise-induced irregular right heart flow dynamics in adolescents and young adults born preterm.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Decreased ventricular size and mass mediate the reduced exercise capacity in adolescents and adults born premature.Early human development · 2021Article
- The Preterm Heart-Brain Axis in Young Adulthood: The Impact of Birth History and Modifiable Risk Factors.Journal of clinical medicine · 2021Article
- Exaggerated Cardiac Contractile Response to Hypoxia in Adults Born Preterm.Journal of clinical medicine · 2021Article
- Reduced handgrip and inspiratory muscle strength are associated with lower lung function and physical capacity in children and adolescents born preterm with very low birth weight.Brazilian journal of physical therapyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposePremature birth is associated with lasting effects, including lower exercise capacity and pulmonary function, and is acknowledged as a risk factor for cardiovascular disease. The aim was to evaluate factors affecting exercise capacity in adolescents born preterm, including the cardiovascular and pulmonary responses to exercise, activity level and strength.
methods21 preterm-born and 20 term-born adolescents (age 12-14 years) underwent strength and maximal exercise testing with thoracic bioimpedance monitoring. Baseline variables were compared between groups and ANCOVA was used to compare heart rate, cardiac output (Q) and stroke volume (SV) during exercise between groups while adjusting for body surface area.
resultsPreterm-borns had lower maximal aerobic capacity than term-borns (2.0 ± 0.5 vs. 2.5 ± 0.5 L/min, p = 0.01) and lower maximal power (124 ± 26 vs. 153 ± 33 watts, p < 0.01), despite similar physical activity scores. Pulmonary function and muscular strength did not differ significantly. Although baseline Q and SV did not differ between groups, preterm adolescents had significantly lower cardiac index (Qi) at 50, 75 and 100% of maximal time to exhaustion, driven by SV volume index (SVi, 50% max time: 53.0 ± 9.0 vs. 61.6 ± 11.4; 75%: 51.7 ± 8.4 vs. 64.3 ± 11.1; 100%: 51.2 ± 9.3 vs. 64.3 ± 11.5 ml/m
conclusionOtherwise healthy and physically active adolescents born very preterm exhibit lower exercise capacity than term-born adolescents. Despite similar baseline cardiovascular values, preterm-born adolescents demonstrate significantly reduced Qi and SVi during incremental and maximal exercise.
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