Evidence map›Paper›PMID 32862241›Full record

ArticleJournal of neurology2021

Common genetic variants in PRRC2A are associated with both neuromyelitis optica spectrum disorder and multiple sclerosis in Han Chinese population.

Juan Zhang, Mei-Jiao Chen, Gui-Xian Zhao, Hong-Fu Li, Lei Wu, Yong-Feng Xu, Yajin Liao, Zengqiang Yuan, Zhi-Ying Wu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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  7. N6-methyladenosine and Neurological Diseases.Molecular neurobiology · 2022
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  8. Genome-Wide Identification ofFrontiers in endocrinology · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Juan ZhangDepartment of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, China.
Mei-Jiao ChenDepartment of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, China.
Gui-Xian ZhaoDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Hong-Fu LiDepartment of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, China.
Lei WuDepartment of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, China.
Yong-Feng XuDepartment of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, China.
Yajin LiaoThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Zengqiang YuanThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Zhi-Ying WuDepartment of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, China. zhiyingwu@zju.edu.cn.
Second Affiliated Hospital of Zhejiang University · CNInstitute of Basic Medical Sciences of the Chinese Academy of Medical SciencesFujian Medical University · CN

Funding

The research foundation for distinguished scholar of Zhejiang University to Zhi-Ying Wu 188020-193810101/089
6 · The paper itself

Abstract

backgroundThe proline-rich coiled-coil 2A (PRRC2A) gene has been reported to underlie risk of various autoimmune diseases. However, no data reveal the risk susceptibility of PRRC2A to neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) so far.

objectivesTo explore the association between PRRC2A variants and NMOSD and MS susceptibility in Han Chinese population.

methodsTotally, 207 NMOSD (98 AQP4

resultsPRRC2A variants rs2736171, rs2736157, rs2844470 alter susceptibility to AQP4

conclusionsPRRC2A variants are first reported to be associated with NMOSD and MS. The identified PRRC2A variants may shed light on the pathogenesis of NMOSD and MS and potentially lead to an individualized therapeutic approach for both distinct disease entities.

Indexed as

Multiple SclerosisNeuromyelitis OpticaAquaporin 4ChinaHumansPolymorphism, Single NucleotideProteinsAquaporin 4ProteinsPRRC2A protein, humanChineseMultiple sclerosisNeuromyelitis optica spectrum disorderPRRC2A

Identifiers

PMID32862241
OpenAlexW3081761364

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.