Evidence map›Paper›PMID 32862238›Full record

Trial reportCancer immunology, immunotherapy : CII2021

Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine storm.

Nicki Panoskaltsis, Neil E McCarthy, Stella C Knight

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer immunology, immunotherapy : CII, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Nicki PanoskaltsisDepartment of Haematology, Imperial College London, Northwick Park and St. Mark's Campus, London, UK. nicki.panoskaltsis@emory.edu.ORCID http://orcid.org/0000-0001-8972-5697
Neil E McCarthyAntigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, London, UK.
Stella C KnightAntigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, London, UK.
Georgia Institute of Technology · USQueen Mary University of London · GBSt Mark's Hospital · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10353Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10355Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10356Cancer Research UK C18928/A8548Medical Research Council MR/R008302/1
6 · The paper itself

Abstract

TGN1412, a superagonist monoclonal antibody targeting CD28, caused cytokine storm in six healthy volunteers in a first-in-man study in 2006. Despite clinical improvement and termination of the cytokine release syndrome within days, anemia persisted in all patients with hemoglobin reaching baseline levels as much as 6 months later. Granulocytic dysplasia continued for 20 days in association with increased expression of CD69 and IL-4, but reduced IL-10; with resolution, this profile reversed to higher IL-10 expression and counter-balanced circannual cycling of IL-4 and IL-10 thereafter over 7 months. Along with immune cell subset and cytokine correlates monitored over 2 years, these observations offer unique insights into the expected changes in myelopoiesis and natural resolution in otherwise healthy young individuals in response to acute inflammation and cytokine storm in the absence of concomitant infection or comorbidity.

Indexed as

AdultAntibodies, Monoclonal, HumanizedCD28 AntigensCytokine Release SyndromeCytokinesHumansInflammationLeukocytes, MononuclearMaleMyelopoiesisYoung AdultAntibodies, Monoclonal, HumanizedCD28 AntigensCytokinesTGN-1412Anemia of inflammationCytokine release syndromeCytokine stormDysgranulopoiesisTGN1412

Identifiers

PMID32862238
PMCPMC10992875
OpenAlexW3081648856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.