ArticleThe British journal of ophthalmology2021
Characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with Leber's hereditary optic neuropathy.
Article in The British journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prenatal and childhood exposure to smoking and retinal nerve fibre layer thickness: A meta-analysis of three independent birth cohorts.Acta ophthalmologica · 2026Pooled it
- Comparison of thickness changes in retinal nerve fibre layer in Leber's hereditary optic neuropathy patients with 11778, 14484 and 3460 mutations.Translational pediatrics · 2025Article
- Clinical follow-up investigation on thickness changes in the peripapillary retinal nerve fibre layer of patients with Leber hereditary optic neuropathy.BMC ophthalmology · 2024Article
- Maculopapillary Bundle Degeneration in Optic Neuropathies.Current neurology and neuroscience reports · 2024Review
- Peripapillary hyperreflective ovoid mass-like structures: multimodal imaging and associated diseases.Frontiers in neurology · 2024Review
- Ocular and inflammatory markers associated with Gulf War illness symptoms.Scientific reports · 2023Article
- The Relative Preservation of the Central Retinal Layers in Leber Hereditary Optic Neuropathy.Journal of clinical medicine · 2022Article
- Clinical application of multicolor imaging in Leber hereditary optic neuropathy.Frontiers in neurology · 2022Article
- Case report: Long-term follow-up of two patients with LHON caused by DNAJC30:c.152G>A pathogenic variant-case series.Frontiers in neurology · 2022Article
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13 authors.
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Abstract
backgroundLimited studies have identified the changes in peripapillary retinal nerve fibre layer (pRNFL) thickness in patients with chronic Leber's hereditary optic neuropathy (LHON) at different stages of the disease. We aimed to characterise the pRNFL thickness changes in patients with LHON having m.11778G>A (
methodsThis retrospective cross-sectional study included 221 eyes from patients with LHON (n=145)-classified into seven groups according to disease duration-and 52 eyes from healthy controls (n=26). All subjects underwent pRNFL examinations. pRNFL thickness of the superior, nasal and inferior, and temporal quadrants, and the 360° average were measured.
resultsWithin 3 months of onset, the temporal pRNFL thickness decreased significantly, whereas the remaining quadrants and the average pRNFL thickness initially increased. The temporal quadrant (p<0.01) and average pRNFL thickness (p=0.02) significantly decreased at 3-6 months. Excluding that in the nasal quadrant (p=0.93), pRNFL thickness significantly decreased in all other quadrants at 6-9 months. At 9-12 months, the average and individual quadrant pRNFL thicknesses continued to decrease. Compared with 12-24 months, the pRNFL thickness was thinner at 24-60 months and >60 months.
conclusionsThe papillomacular bundle was affected first and preferentially in LHON. pRNFL thickness initially increased and then decreased, corresponding to the retinal ganglion cell swelling and apoptosis. pRNFL thinning first occurred in the temporal quadrant, followed by the inferior and superior quadrants, and finally, the nasal quadrant. pRNFL continued to thin slowly in some quadrants even after 60 months.
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