Evidence map›Paper›PMID 32861851›Full record

ArticleOsteoarthritis and cartilage2020

The association between walking speed from short- and standard-distance tests with the risk of all-cause mortality among adults with radiographic knee osteoarthritis: data from three large United States cohort studies.

H Master, T Neogi, L F Callahan, A E Nelson, M LaValley, R J Cleveland, Y M Golightly, L M Thoma, Y Zhang, D Voinier and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

H MasterDepartment of Physical Therapy, College of Health Sciences, University of Delaware, Newark, DE, USA; Biomechanics and Movement Science Interdisciplinary Program, University of Delaware, Newark, DE, USA; Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: hiral@udel.edu.
T NeogiDepartment of Medicine, Section of Rheumatology, Boston University School of Medicine, Boston, MA, USA.
L F CallahanDepartments of Social Medicine and Orthopedics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, NC, USA.
A E NelsonDepartment of Medicine, Division of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, NC, USA.
M LaValleySchool of Public Health, Boston University, Boston, MA, USA.
R J ClevelandDepartment of Medicine, Division of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, NC, USA.
Y M GolightlyThurston Arthritis Research Center, University of North Carolina at Chapel Hill, NC, USA; Division of Physical Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Epidemiology, University of North Carolina at Chapel Hill, NC, USA; Injury Prevention Research Center, University of North Carolina at Chapel Hill, NC, USA.
L M ThomaDivision of Physical Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Y ZhangDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
D VoinierDepartment of Physical Therapy, College of Health Sciences, University of Delaware, Newark, DE, USA; Biomechanics and Movement Science Interdisciplinary Program, University of Delaware, Newark, DE, USA.
M B ChristiansenDepartment of Physical Therapy, College of Health Sciences, University of Delaware, Newark, DE, USA; Biomechanics and Movement Science Interdisciplinary Program, University of Delaware, Newark, DE, USA.
J T JakielaDepartment of Physical Therapy, College of Health Sciences, University of Delaware, Newark, DE, USA; Biomechanics and Movement Science Interdisciplinary Program, University of Delaware, Newark, DE, USA.
M NevittDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
C E LewisDepartment of Epidemiology, University of Alabama, Birmingham, AL, USA.
L A Frey-LawDepartment of Physical Therapy and Rehabilitation Sciences, University of Iowa, Iowa City, IA, USA.
D K WhiteDepartment of Physical Therapy, College of Health Sciences, University of Delaware, Newark, DE, USA; Biomechanics and Movement Science Interdisciplinary Program, University of Delaware, Newark, DE, USA.
University of Delaware · USUniversity of North Carolina at Chapel Hill · USBoston University · USHarvard University · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Iowa · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6M
Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2M
MULTICENTER CAREER DEVELOPMENT PROGRAM FOR PHYSICAL AND OCCUPATIONAL THERAPYK12HD055931 · NICHD · WASHINGTON UNIVERSITY · PI HAYES, MARCIE HARRIS · 2007 to 2021
$12.7M
Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEIGH Fleming CALLAHAN, Amanda E Nelson · 2019 to 2026
$6.1M
NIAMS Multidisciplinary Clinical Research CenterP60AR064166 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHWARTZ, TODD A · 2013 to 2017
$5.8M
PT/PHD Predoctoral Training Program Diversity SupplementT32HD007490 · NICHD · UNIVERSITY OF DELAWARE · PI DARCY S. REISMAN · 1996 to 2026
$3.7M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
Mortality in a community sample of adults with arthritisR01AR065937 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CALLAHAN, LEIGH FLEMING, JORDAN, JOANNE M. · 2013 to 2016
$1.1M
ACL HHS U01DP003206NIAMS NIH HHS F32 AR073090NIAMS NIH HHS K23 AR070913NIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR072571NIAMS NIH HHS P30 AR072580NIAMS NIH HHS P60 AR064166NIAMS NIH HHS R01 AR065937NIAMS NIH HHS R21 AR071079NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NICHD NIH HHS K12 HD055931NICHD NIH HHS T32 HD007490NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

objectiveAdults with radiographic knee OA (rKOA) are at increased risk of mortality and walking difficulty may modify this relation. Little is known about specific aspects of walking difficulty that increase mortality risk. We investigated the association of walking speed (objective measure of walking difficulty) with mortality and examined the threshold that best discriminated this risk in adults with rKOA.

methodsParticipants with rKOA from the Johnston County Osteoarthritis Project (JoCoOA, longitudinal population-based cohort), Osteoarthritis Initiative and Multicenter Osteoarthritis Study (OAI and MOST, cohorts of individuals with or at high risk of knee OA) were included. Baseline speed was measured via 2.4-meter (m) walk test (short-distance) in JoCoOA and 20-m walk test (standard-distance) in OAI and MOST. To examine the association of walking speed with mortality risk over 9 years, hazard ratios (HR) and 95% confidence intervals (CI) were calculated from Cox regression models adjusted for potential confounders. A Maximal Likelihood Ratio Chi-square Approach was utilized to identify an optimal threshold of walking speed predictive of mortality.

resultsDeaths after 9 years of follow-up occurred in 23.3% (290/1244) of JoCoOA and 5.9% (249/4215) of OAI + MOST. Walking 0.2 m/s slower during short- and standard-distance walk tests was associated with 23% (aHR [95%CI]; 1.23 [1.10, 1.39]) and 25% (1.25 [1.09, 1.43]) higher mortality risk, respectively. Walking <0.5 m/s on short-distance and <1.2 m/s standard-distance walk tests, best discriminated those with and without mortality risk.

conclusionSlower walking speed measured via short- and standard-distance walk tests was associated with increased mortality risk in adults with rKOA.

Indexed as

AgedCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedMortalityOsteoarthritis, KneeUnited StatesWalking SpeedArthritisDeathGait speedPerformance-based measuresPhysical function

Identifiers

PMID32861851
PMCPMC7722103
OpenAlexW3080387981

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