Evidence map›Paper›PMID 32861841›Full record

Trial reportJournal of affective disorders2020

Longitudinal trajectories of mood symptoms and global functioning in youth at high risk for bipolar disorder.

Marc J Weintraub, Christopher D Schneck, Patricia D Walshaw, Kiki D Chang, Aimee E Sullivan, Manpreet K Singh, David J Miklowitz

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of affective disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Risk Factors Associated with Longitudinal Trajectories of Mania Symptoms in Youth.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marc J WeintraubSemel Institute of Neuroscience and Human Behavior, University of California, 760 Westwood Plaza, A7-370, Los Angeles 90095, CA, USA. Electronic address: mjweintraub@mednet.ucla.edu.
Christopher D SchneckSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Patricia D WalshawSemel Institute of Neuroscience and Human Behavior, University of California, 760 Westwood Plaza, A7-370, Los Angeles 90095, CA, USA.
Kiki D ChangPrivate Practice, Menlo Park, CA, USA.
Aimee E SullivanSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Manpreet K SinghSchool of Medicine, Stanford University, Palo Alto, CA, USA.
David J MiklowitzSemel Institute of Neuroscience and Human Behavior, University of California, 760 Westwood Plaza, A7-370, Los Angeles 90095, CA, USA.

Funding

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy TrialR01MH123575 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, MIKLOWITZ, DAVID JAY · 2020 to 2023
$5.4M
1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Neurodevelopment and Psychosis in the 22q11.2 Copy Number VariantsR37MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARRIE E BEARDEN · 2023 to 2026
$2.9M
2/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093666 · NIMH · STANFORD UNIVERSITY · PI HARDAN, ANTONIO · 2012 to 2016
$2.0M
Technology-Enhanced Family-Focused Treatment for Adolescents at High Risk for Mood DisordersR34MH117200 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AREVIAN, ARMEN C, MIKLOWITZ, DAVID JAY · 2018 to 2020
$933k
Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar DisorderR34MH077856 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2007 to 2009
$638k
NIMH NIH HHS R01 MH093666NIMH NIH HHS R01 MH093676NIMH NIH HHS R01 MH123575NIMH NIH HHS R34 MH077856NIMH NIH HHS R34 MH117200NIMH NIH HHS R37 MH085953
6 · The paper itself

Abstract

backgroundLittle is known about the longitudinal course of mood symptoms and functioning in youth who are at high risk for bipolar disorder (BD). Identifying distinct course trajectories and predictors of those trajectories may help refine treatment approaches.

methodsThis study examined the longitudinal course of mood symptoms and functioning ratings in 126 youth at high risk for BD based on family history and early mood symptoms. Participants were enrolled in a randomized trial of family-focused therapy and followed longitudinally (mean 2.0 years, SD = 53.6 weeks).

resultsUsing latent class growth analyses (LCGA), we observed three mood trajectories. All youth started the study with active mood symptoms. Following the index mood episode, participants were classified as having a "significantly improving course" (n = 41, 32.5% of sample), a "moderately symptomatic course" (n = 21, 16.7%), or a "predominantly symptomatic course" (n = 64, 50.8%) at follow-up. More severe depression, anxiety, and suicidality at the study's baseline were associated with a poorer course of illness. LCGA also revealed three trajectories of global functioning that closely corresponded to symptom trajectories; however, fewer youth exhibited functional recovery than exhibited symptomatic recovery. LIMITATIONS: Mood trajectories were assessed within the context of a treatment trial. Ratings of mood and functioning were based on retrospective recall.

conclusionsThis study suggests considerable heterogeneity in the course trajectories of youth at high risk for BD, with a significant proportion (32.5%) showing long-term remission of symptoms. Treatments that enhance psychosocial functioning may be just as important as those that ameliorate symptoms in youth at risk for BD.

Indexed as

Bipolar DisorderAdolescentAffectAnxiety DisordersFamily TherapyHumansRetrospective StudiesDepressionFamilial riskIllness courseManiaPediatricPrognosis

Identifiers

PMID32861841
PMCPMC7572604

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.