Evidence map›Paper›PMID 32861645›Full record

ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2020

Impact of sleeve gastrectomy on hip structural analysis in adolescents and young adults with obesity.

Madhusmita Misra, Abisayo Animashaun, Amita Bose, Vibha Singhal, Fatima Cody Stanford, Brian Carmine, Miriam A Bredella

Open access · greenAbstract read
In one paragraph

Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Bone Metabolism in Adolescents Undergoing Bariatric Surgery.The Journal of clinical endocrinology and metabolism · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Madhusmita MisraNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Pediatric Endocrinology, Mass General Hospital for Children and Harvard Medical School, Boston, Massachusetts. Electronic address: mmisra@mgh.harvard.edu.
Abisayo AnimashaunNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Amita BoseNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Pediatric Endocrinology, Mass General Hospital for Children and Harvard Medical School, Boston, Massachusetts; MGH Weight Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Vibha SinghalNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Pediatric Endocrinology, Mass General Hospital for Children and Harvard Medical School, Boston, Massachusetts; MGH Weight Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Fatima Cody StanfordNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Pediatric Endocrinology, Mass General Hospital for Children and Harvard Medical School, Boston, Massachusetts; MGH Weight Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Brian CarmineDepartment of Surgery, Boston Medical Center, Boston, Massachusetts.
Miriam A BredellaDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Harvard University · USMassachusetts General Hospital · USBoston Medical Center · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HALL, JANET E · 1985 to 2008
$37.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2000 to 2019
$31.4M
The Role of Estrogen in the Neurobiology of Eating Disorders: A Study of Cognitive Flexibility and Reward in Eating DisordersR01MH116205 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, MISRA, MADHUSMITA · 2019 to 2023
$4.7M
Homeostatic and Hedonic Food Motivation Underlying Eating Disorder TrajectoriesR01MH103402 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, LAWSON, ELIZABETH AUSTEN · 2014 to 2018
$3.7M
Bone Metabolism in Adolescents Undergoing Bariatric SurgeryR01DK103946 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BREDELLA, MIRIAM ANTOINETTE, MISRA, MADHUSMITA · 2015 to 2019
$3.2M
Fat Mediated Modulation of Reproductive and Endocrine Function in Young AthletesR01HD060827 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MISRA, MADHUSMITA · 2009 to 2013
$2.4M
Determinants of bone microarchitectural compromise in youth with type 1 diabetesR01DK122581 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BOUXSEIN, MARY L, MISRA, MADHUSMITA · 2019 to 2023
$2.0M
Determinants of Beta Cell Function Following Sleeve Gastrectomy in AdolescentsK23DK110419 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SINGHAL, VIBHA · 2016 to 2021
$1.1M
Bone Metabolism in Adolescents UndergoingBariatric SurgeryK24DK109940 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BREDELLA, MIRIAM ANTOINETTE · 2017 to 2021
$970k
Bone Metabolism and Body Composition in Young AthletesK24HD071843 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MISRA, MADHUSMITA · 2013 to 2017
$930k
NCATS NIH HHS UL1 TR002541NCRR NIH HHS K23 RR018851NCRR NIH HHS M01 RR001066NICHD NIH HHS K24 HD071843NICHD NIH HHS R01 HD060827NIDDK NIH HHS K23 DK110419NIDDK NIH HHS K24 DK109940NIDDK NIH HHS L30 DK118710NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK103946NIDDK NIH HHS R01 DK122581NIMH NIH HHS R01 MH103402NIMH NIH HHS R01 MH116205
6 · The paper itself

Abstract

backgroundSleeve gastrectomy (SG), the most commonly performed metabolic and bariatric surgery, is associated with reductions in areal bone mineral density at multiple sites, and changes in bone structure at the distal radius and tibia without reductions in strength estimates at these peripheral sites. Data are lacking regarding effects on hip strength estimates.

objectiveTo evaluate effects of SG on measures of hip structural analysis in adolescents and young adults over 12 months using dual-energy x-ray absorptiometry. SETTINGS: Translational and Clinical Research Center.

methodsWe enrolled 48 youth 14- to 22-years old with moderate-to-severe obesity; 24 underwent SG and 24 controls were followed without surgery (18 females, 6 males in each group). Hip structure was assessed using dual-energy x-ray absorptiometry at baseline and 12 months. Analyses are adjusted for age, sex, race, and the baseline bone measure.

resultsThe SG group lost 25.9% weight versus .3% in controls. Compared with controls, SG had reductions in narrow neck, intertrochanteric and femoral shaft bone mineral density Z-scores (P ≤ .012). Furthermore, SG had greater reductions in narrow neck and intertrochanteric region (but not femoral shaft) cross-sectional area, cortical thickness, cross-sectional moment of inertia and section modulus, and increases in buckling ratio (P ≤ .039). Differences were attenuated after adjusting for 12-month body mass index change. At 12 months, differences were minimal after adjusting for age, sex, race, and weight.

conclusionsOver 12 months, SG had negative effects at the narrow neck and intertrochanteric regions of the hip, but not the femoral shaft. Reduced body mass index may compensate for these deleterious effects on bone.

Indexed as

Bone DensityObesityAbsorptiometry, PhotonAdolescentAdultFemaleFemurGastrectomyHumansMaleYoung AdultAdolescentsBone strengthBone structureHip structural analysisMetabolic and bariatric surgerySleeve gastrectomy

Identifiers

PMID32861645
PMCPMC7704626
OpenAlexW3046694303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.