ArticleJournal de mycologie medicale2020
Fatal aspergillosis complicating severe SARS-CoV-2 infection: A case report.
Article in Journal de mycologie medicale, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- A systematic review on impact of SARS-CoV-2 infection.Microbiological research · 2023Pooled it
- CT findings of COVID-19-associated pulmonary aspergillosis: a systematic review and individual patient data analysis.Clinical imaging · 2022Pooled it
- Antifungal therapy in the management of fungal secondary infections in COVID-19 patients: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Review
- Comparative risk assessment of COVID-19 associated mucormycosis and aspergillosis: A systematic review.Health science reports · 2022Article
- Clinical and Imaging Features of COVID-19-Associated Pulmonary Aspergillosis.Diagnostics (Basel, Switzerland) · 2022Article
- Pathogenesis of Respiratory Viral and Fungal Coinfections.Clinical microbiology reviews · 2022Review
- A post-COVID-19SAGE open medical case reports · 2022Article
- Fungal Infection in Co-infected Patients With COVID-19: An Overview of Case Reports/Case Series and Systematic Review.Frontiers in microbiology · 2022Review
- Invasive Fungal Infections Complicating COVID-19: A Narrative Review.Journal of fungi (Basel, Switzerland) · 2021Review
- Incidence and Risk Factors of COVID-19-Associated Pulmonary Aspergillosis in Intensive Care Unit-A Monocentric Retrospective Observational Study.Pathogens (Basel, Switzerland) · 2021Article
- COVID-19-Associated Pulmonary Aspergillosis (CAPA).Journal of intensive medicine · 2021Review
- Overview on the Prevalence of Fungal Infections, Immune Response, and Microbiome Role in COVID-19 Patients.Journal of fungi (Basel, Switzerland) · 2021Review
- A review of significance of Aspergillus detection in airways of ICU COVID-19 patients.Mycoses · 2021Review
- Proven Aspergillus flavus pulmonary aspergillosis in a COVID-19 patient: A case report and review of the literature.Mycoses · 2021Review
- State-of-the-art review of secondary pulmonary infections in patients with COVID-19 pneumonia.Infection · 2021Review
- Epidemiology of Systemic Mycoses in the COVID-19 Pandemic.Journal of fungi (Basel, Switzerland) · 2021Review
- COVID-19-Associated Pulmonary Aspergillosis, March-August 2020.Emerging infectious diseases · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As aspergillosis is a well-known complication of severe influenza, we suggest that SARS-CoV-2 might be a risk factor for invasive aspergillosis (IA). We report the case of an 87 year-old woman, with no history of immune deficit, admitted in our emergency room for severe respiratory distress. Coronavirus disease 2019 (COVID-19) diagnosis was confirmed by a SARS-CoV-2 reverse transcriptase polymerase chain reaction (PCR) on nasal swab. On day 14, pulmonary examination deteriorated with haemoptysis and a major increase of inflammatory response. A computed tomography (CT) scan revealed nodules highly suggestive of IA. Aspergillus antigen was found highly positive in sputum and blood, as was Aspergillusspp PCR on serum. Sputum cultures remained negative for Aspergillus. This patient died rapidly from severe respiratory failure, despite the addition of voriconazole. Considering SARS-CoV-2 acute respiratory distress syndrome (ARDS) as an acquired immunodeficiency, we report here a new case of "probable" IA based on clinical and biological arguments, in accordance with the last consensus definition of invasive fungal disease. On a routine basis, we have detected 30% of aspergillosis carriage (positive culture and antigen in tracheal secretions) in critically ill patients with COVID-19 in our centre. Further studies will have to determine whether sputum or tracheal secretions should be systematically screened for fungal investigations in intensive care unit (ICU) COVID-19 patients to early diagnose and treat aspergillosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.