Evidence map›Paper›PMID 32861513›Full record

ReviewTrends in biochemical sciences2020

Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function.

Amr Ellaithy, Javier Gonzalez-Maeso, Diomedes A Logothetis, Joshua Levitz

Open access · greenAbstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 106 citations in OpenAlex.

  1. Review
  2. Article
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  8. Review
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  12. A biased allosteric modulator functions as a molecular glue to induce βbioRxiv : the preprint server for biology · 2025
    Article
  13. Review
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  17. Review
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Amr EllaithyDepartment of Neurology, University of Iowa, Iowa City, IA 52242, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Javier Gonzalez-MaesoDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Diomedes A LogothetisDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, USA; Department of Chemistry and Chemical Biology, College of Science and Center for Drug Discovery, Northeastern University, Boston, MA 02115, USA.
Joshua LevitzDepartment of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: jtl2003@med.cornell.edu.
Cornell University · USMassachusetts General Hospital · USNortheastern University · USVirginia Commonwealth University · US

Funding

Structural Determinants of PIP2 RegulationR01HL059949 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Leigh Daniel Plant · 1998 to 2026
$11.6M
Structure and function of the 5HT2A/mGluR2 complex in schizophreniaR01MH084894 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Javier Gonzalez-Maeso · 2009 to 2026
$6.8M
Molecular Mechanisms of Synaptic G Protein-Coupled ReceptorsR35GM124731 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITZ, JOSHUA · 2017 to 2021
$2.1M
Preclinical role of HDAC2 in mGlu2-dependent schizophrenia treatmentR01MH111940 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI GONZÁLEZ-MAESO, JAVIER · 2017 to 2021
$1.5M
NHLBI NIH HHS R01 HL059949NIGMS NIH HHS R35 GM124731NIMH NIH HHS R01 MH084894NIMH NIH HHS R01 MH111940
6 · The paper itself

Abstract

Groundbreaking structural and spectroscopic studies of class A G protein-coupled receptors (GPCRs), such as rhodopsin and the β

Indexed as

Biophysical PhenomenaReceptors, Metabotropic GlutamateLigandsProtein DomainsProtein Structure, SecondarySignal TransductionLigandsReceptors, Metabotropic Glutamatecalcium-sensing receptorGABA(B) receptorG protein-coupled receptorsmetabotropic glutamate receptor

Identifiers

PMID32861513
PMCPMC7642020
OpenAlexW3080364644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.