Evidence map›Paper›PMID 32861268›Full record

ArticleCell metabolism2020

Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes.

Xu Cheng, Ye-Mao Liu, Haomiao Li, Xin Zhang, Fang Lei, Juan-Juan Qin, Ze Chen, Ke-Qiong Deng, Lijin Lin, Ming-Ming Chen and 25 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 14 pooled it
3.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 14 syntheses or guidelines pooled it, 165 citations in OpenAlex.

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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 13 institutions in 3 countries.

Xu ChengDepartment of Cardiology, Zhongnan Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Ye-Mao LiuInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Haomiao LiInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Xin ZhangInstitute of Model Animal, Wuhan University, Wuhan, China.
Fang LeiDepartment of Cardiology, Zhongnan Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Juan-Juan QinInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Ze ChenInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Ke-Qiong DengDepartment of Cardiology, Zhongnan Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China.
Lijin LinInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Ming-Ming ChenInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Xiaohui SongInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Meng XiaInstitute of Model Animal, Wuhan University, Wuhan, China.
Xuewei HuangInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Weifang LiuDepartment of Cardiology, Zhongnan Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Jingjing CaiDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410000, China.
Xiao-Jing ZhangInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Feng ZhouInstitute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Peng ZhangInstitute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yibin WangDepartments of Anesthesiology, Physiology, and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Xinliang MaDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19004, USA.
Qingbo XuCentre for Clinic Pharmacology, The William Harvey Research Institute, Queen Mary University of London, London, UK.
Juan YangInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Ping YeDepartment of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Weiming MaoDepartment of General Surgery, Huanggang Central Hospital, Huanggang, China.
Xiaodong HuangDepartment of Gastroenterology, Wuhan Third Hospital and Tongren Hospital of Wuhan University, Wuhan, China.
Jiahong XiaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Bing-Hong ZhangDepartment of Neonatology, Renmin Hospital of Wuhan University, Wuhan, China.
Jiao GuoGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine & Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China & Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China.
Lihua ZhuInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Zhibing LuDepartment of Cardiology, Zhongnan Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China.
Yufeng YuanDepartment of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: yuanyf1971@whu.edu.cn.
Xiang WeiDivision of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: xiangwei@tjh.tjmu.edu.cn.
Zhi-Gang SheInstitute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: zgshe@whu.edu.cn.
Yan-Xiao JiInstitute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: jiyanxiao@whu.edu.cn.
Hongliang LiDepartment of Cardiology, Zhongnan Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: lihl@whu.edu.cn.
Wuhan University · CNRenmin Hospital of Wuhan University · CNZhongnan Hospital of Wuhan University · CNCentral Hospital of Wuhan · CNGuangdong Pharmaceutical University · CNHuanggang Central Hospital · CNHuazhong University of Science and Technology · CNThird Xiangya Hospital · CNThomas Jefferson University · USTongren Hospital · CNUnion Hospital · CNUniversity of California, Los Angeles · USWilliam Harvey Research Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The safety and efficacy of anti-diabetic drugs are critical for maximizing the beneficial impacts of well-controlled blood glucose on the prognosis of individuals with COVID-19 and pre-existing type 2 diabetes (T2D). Metformin is the most commonly prescribed first-line medication for T2D, but its impact on the outcomes of individuals with COVID-19 and T2D remains to be clarified. Our current retrospective study in a cohort of 1,213 hospitalized individuals with COVID-19 and pre-existing T2D indicated that metformin use was significantly associated with a higher incidence of acidosis, particularly in cases with severe COVID-19, but not with 28-day COVID-19-related mortality. Furthermore, metformin use was significantly associated with reduced heart failure and inflammation. Our findings provide clinical evidence in support of continuing metformin treatment in individuals with COVID-19 and pre-existing T2D, but acidosis and kidney function should be carefully monitored in individuals with severe COVID-19.

Indexed as

AcidosisAcidosis, LacticAgedChinaCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2FemaleHospitalizationHumansKidneyMaleMetforminMiddle AgedPandemicsPneumonia, ViralMetforminacidosiscoronavirus disease 2019inflammationmetforminmortalitytreatment

Identifiers

PMID32861268
PMCPMC7439986
OpenAlexW3073804858

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.