Evidence map›Paper›PMID 32861152›Full record

ArticleSeizure2020

Status epilepticus and other EEG findings in patients with COVID-19: A case series.

Wendy Chen, Sheela Toprani, Katherine Werbaneth, Jessica Falco-Walter

Open access · bronzeAbstract read
In one paragraph

Article in Seizure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Observational
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The value of EEG attenuation in the prediction of outcome in COVID-19 patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  14. Review
  15. Article
  16. Seizures and COVID-19: Results from the Spanish Society of Neurology's COVID-19 registry.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022
    Observational
  17. Review
  18. Status epilepticus due to COVID-19; a cases series and literature review.American journal of neurodegenerative disease · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wendy ChenDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. Electronic address: chenzw9@gmail.com.
Sheela TopraniDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Katherine WerbanethDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Jessica Falco-WalterDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Stanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeurological manifestations of COVID-19 infection include impaired consciousness, strokes, and seizures. Limited reports describing EEG abnormalities in patients with COVID-19 have been published. These articles reported nonspecific encephalopathic patterns, epileptiform discharges, and rarely seizures. Our primary aim was to assess EEG abnormalities in patients with COVID-19 and evaluate for epileptiform activity or seizures.

methodsWe identified five critically ill adult patients with COVID-19 who underwent EEG monitoring. All patients had Ceribell™ rapid response EEG initially and two continued with conventional long-term video EEG.

resultsAll 5 patients had encephalopathy and 3 also had seizure-like movements, thus prompting EEG monitoring. EEGs all showed nonspecific markers of encephalopathy including diffuse slowing and generalized rhythmic delta activity. Two also had epileptiform discharges reaching 2-3 Hz at times, with one patient in nonconvulsive status epilepticus and the other developing clinical status epilepticus with myoclonic movements. EEG and clinical symptoms improved with anti-seizure medications.

conclusionStatus epilepticus was present in 2 out of our cohort of 5 critically ill patients who underwent EEG monitoring. These findings highlight the importance of EEG monitoring in high-risk patients with COVID-19 and encephalopathy. EEG recordings in such patients can identify pathological patterns that will benefit from treatment with anti-seizure medications.

Indexed as

AdultBetacoronavirusBrain DiseasesCoronavirus InfectionsCOVID-19ElectroencephalographyFemaleHumansMaleMiddle AgedPandemicsPneumonia, ViralRetrospective StudiesSARS-CoV-2SeizuresStatus EpilepticusCase seriesCOVID-19EEGEncephalopathySeizures

Identifiers

PMID32861152
PMCPMC7441944
OpenAlexW3080334780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.