ArticleJournal of the American Academy of Child and Adolescent Psychiatry2020
Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Understanding irritability through the lens of self-regulatory control processes in children and adolescents: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- Developmental trajectories of prefrontal activation underlying emotional inhibitory control from adolescence to young adulthood: a functional near-infrared spectroscopy study.Behavioral and brain functions : BBF · 2026Article
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Inhibition-related connectivity predicts irritability risk and resilience across early adolescence.Social cognitive and affective neuroscience · 2026Article
- Resting-state EEG markers associated with violence risk in patients with major depressive disorder.Psychological medicine · 2026Article
- Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents.Journal of mood and anxiety disorders · 2025Article
- Investigating cross-sectional and longitudinal relationships between brain structure and distinct dimensions of externalizing psychopathology in the ABCD sample.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Structural Brain Correlates of Anxiety During Development.Current topics in behavioral neurosciences · 2025Review
- Leveraging technology to probe mechanisms of psychopathology: A proof of concept study of inhibitory control.PloS one · 2025Article
- Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neural mechanisms of inhibitory control in preadolescent irritability: Insights from the ABCD study.Biological psychology · 2024Article
- Article
- Categorical and dimensional approaches to the developmental relationship between ADHD and irritability.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Keeping up with the kids: the value of co-production in the study of irritability in youth depression and its underlying neural circuitry.Frontiers in behavioral neuroscience · 2023Review
- Executive functioning moderates neural mechanisms of irritability during reward processing in youth.Psychiatry research. Neuroimaging · 2022Article
- Associations of Irritability With Functional Connectivity of Amygdala and Nucleus Accumbens in Adolescents and Young Adults With ADHD.Journal of attention disorders · 2022Article
- Characterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®.Frontiers in psychiatry · 2022Article
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Authors and funding
32 authors at 16 institutions in 7 countries.
Funding
Abstract
objectiveIrritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries.
methodThe Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses.
resultsWhole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume.
conclusionThis study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.
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