ArticleClinical transplantation2020
Viability testing of discarded livers with normothermic machine perfusion: Alleviating the organ shortage outweighs the cost.
Article in Clinical transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Article
- Deep-learning-Assisted Photoacoustic and Ultrasound Evaluation for Pre-transplant Human Liver Graft Quality and Transplant Suitability.medRxiv : the preprint server for health sciences · 2026Article
- Cryopreservation Strategies to Improve Access to Organ Transplantation.Transplantation · 2026Review
- Revealing the potential of non-transplanted donor organs: a comparative analysis in the Eurotransplant region.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Liver transplantation: embracing the future with machine perfusion.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026Review
- Ex vivo machine perfusion as a platform for lentiviral gene delivery in rat livers.Gene therapy · 2025Article
- Survey of Early Practices and Perceptions of Liver Machine Perfusion Among US Liver Transplant Surgeons.Transplantation direct · 2025Article
- Transforming the logistics of liver transplantation with normothermic machine perfusion: Clinical impact versus cost.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025Article
- Machine Perfusion in an Ageing Population - Results From a German, National Survey Among Transplant Centers.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Comment on "Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multi-Center, Real-World Risk-Matched Analysis".Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Optimized partial freezing protocol enables 10-day storage of rat livers.Scientific reports · 2024Article
- Combined Organ Transplantation in Patients with Advanced Liver Disease.Seminars in liver disease · 2024Review
- Optimized Partial Freezing Protocol Enables 10-Day Storage of Rat Livers.Research square · 2024Article
- Critical Evaluation of Discarded Donor Livers in the Eurotransplant Region: Potential Implications for Machine Perfusion.Annals of transplantation · 2023Article
- Current practice and novel approaches in organ preservation.Frontiers in transplantation · 2023Review
- Changing liver utilization and discard rates in clinical transplantation in the ex-vivo machine preservation era.Frontiers in medical technology · 2023Review
- Hyperspectral Imaging for Viability Assessment of Human Liver Allografts During Normothermic Machine Perfusion.Transplantation direct · 2022Article
- A Novel Digital Algorithm for Identifying Liver Steatosis Using Smartphone-Captured Images.Transplantation direct · 2022Article
- Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigatesFrontiers in immunology · 2022Article
- Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundOver 700 donor livers are discarded annually in the United States due to high risk of poor graft function. The objective of this study was to determine the impact of using normothermic machine perfusion to identify transplantable livers among those currently discarded. STUDY
designA series of 21 discarded human livers underwent viability assessment during normothermic machine perfusion. Cross-sectional analysis of the Scientific Registry of Transplant Recipients database and cost analysis was performed to extrapolate the case series to national experience.
results21 discarded human livers were included in the perfusion cohort. 11 of 20 (55%) eligible grafts met viability criteria for transplantation. Grafts in the perfusion cohort had a similar donor risk index compared with discarded grafts (n = 1402) outside of New England in 2017 and 2018 (median [IQR]: 2.0 [1.5, 2.4] vs. 2.0 [1.7, 2.3], P = .40). 705 (IQR 677-741) livers were discarded annually in the United States since 2005, translating to the potential for 398 additional transplants nationally. The median cost to identify a transplantable graft with machine perfusion was $28,099 USD.
conclusionsNormothermic machine perfusion of discarded livers could identify a significant number of transplantable grafts, significantly improving access to liver transplantation.
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