ArticleEuropean journal of nutrition2021
Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract.
Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 46 citations in OpenAlex.
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- Genistein Promotes Anti-Heat Stress and Antioxidant Effects via the Coordinated Regulation of IIS, HSP, MAPK, DR, and Mitochondrial Pathways inAntioxidants (Basel, Switzerland) · 2023Article
- Preparation ofMolecules (Basel, Switzerland) · 2022Article
- Molecular Mechanisms for Anti-aging of Low-Vacuum Cold Plasma Pretreatment in Caenorhabditis elegans.Applied biochemistry and biotechnology · 2022Article
- Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies.International journal of molecular sciences · 2022Review
- Anti-Aging Effect ofMolecules (Basel, Switzerland) · 2022Article
- Stress Buffering and Longevity Effects of Amber Extract onMolecules (Basel, Switzerland) · 2022Article
- Oxidation and Antioxidation of Natural Products in the Model OrganismAntioxidants (Basel, Switzerland) · 2022Review
- Sea cucumber (Frontiers in nutrition · 2022Article
- Extraction, Purification, Physicochemical Properties, and Activity of a New Polysaccharide FromFrontiers in nutrition · 2022Article
- Saponins from bitter melon reduce lipid accumulation via induction of autophagy inCurrent research in food science · 2022Article
- Phosphorothioate-DNA bacterial diet reduces the ROS levels in C. elegans while improving locomotion and longevity.Communications biology · 2021Article
- Neurorescue Effects of Frondoside A and Ginsenoside Rg3 inMolecules (Basel, Switzerland) · 2021Article
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7 authors at 1 institution in 1 country.
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Abstract
backgroundMomordica saponin extract (MSE) was found to not only improve longevity and neuroprotection but also alleviate fat accumulation in Caenorhabditis elegans in our previous study. However, the lipid-lowering activity of MSE alone could not fully explain its ability to improve health, so the antistress effects of MSE were further studied.
methodsUsing C. elegans as an in vivo animal, the lifespan of MSE-treated C. elegans under various stressors (H
resultsMSE significantly improved the lifespan of C. elegans under stress and normal conditions. Meanwhile, the mobility of C. elegans was also improved. Moreover, the activities of SOD and CAT and the ratio of GSH/GSSG were elevated. Consistently, the levels of ROS and lipid oxidation (the NEFA and MDA content) were reduced. Furthermore, MSE treatment upregulated the expression of the sod-3, sod-5, clt-1, clt-2, hsp-16.1 and hsp-16.2 genes. All biomarkers indicated that the antistress and anti-aging activities of MSE were due to its strong antioxidant activities. Finally, MSE induced nuclear DAF-16::GFP localization. Studies with mutants revealed that skn-1 and hsf-1 were involved in the activity of MSE, which might upregulate the expression of downstream stress-responsive genes.
conclusionsTherefore, in addition to its lipid-lowering property, the ability of MSE to improve healthspan was also attributed to the stress resistance effect. Together, MSE might serve as a lead nutraceutical in geriatric research.
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