Evidence map›Paper›PMID 32860355›Full record

ArticleAnnals of clinical and translational neurology2020

Serum levels of cell adhesion molecules in patients with neuromyelitis optica spectrum disorder.

Bao-Luen Chang, Long-Sun Ro, Chiung-Mei Chen, Yen-Shi Lo, Rong-Kuo Lyu, Hung-Chou Kuo, Ming-Feng Liao, Chun-Wei Chang, Hong-Shiu Chang, Ching-Chang Huang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Biomarkers of blood-brain barrier and neurovascular unit integrity in human cognitive impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  3. Article
  4. Blood-Brain Barrier Disruption in Neuroimmunological Disease.International journal of molecular sciences · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Bao-Luen ChangDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.ORCID 0000-0002-4547-6155
Long-Sun RoDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Chiung-Mei ChenDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Yen-Shi LoDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Rong-Kuo LyuDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Hung-Chou KuoDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Ming-Feng LiaoDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.ORCID 0000-0001-7908-4267
Chun-Wei ChangDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Hong-Shiu ChangDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Ching-Chang HuangDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Yih-Ru WuDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Chun-Che ChuDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Yi-Ching WengDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.
Kuo-Hsuan ChangDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, No. 5, Fusing St., Gueishan Dist., Taoyuan City, 333, Taiwan.ORCID 0000-0003-4972-9823
Chang Gung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesBlood-brain barrier (BBB) disruption is a critical pathological process involved in neuromyelitis optica spectrum disorder (NMOSD). Here, we characterized the profile of five cell adhesion molecules in patients with NMOSD.

methodsWe measured levels of cell adhesion molecules, including ICAM-1, ICAM-2, VCAM-1, PECAM-1, and NCAM-1, in the serum of 28 patients with NMOSD, 24 patients with multiple sclerosis (MS), and 25 healthy controls (HCs).

resultsICAM-2 levels (median: 394.8 ng/mL) were increased in patients with NMOSD compared with MS (267.1 ng/mL, P = 0.005) and HCs (257.4 ng/mL, P = 0.007), and VCAM-1 and ICAM-1 levels were higher in patients with NMOSD (641.9 ng/mL and 212.7 ng/mL, respectively) compared with HCs (465 ng/mL [P = 0.013] and 141.8 ng/mL [P = 0.002], respectively). However, serum PECAM-1 levels were lower in patients with NMOSD (89.62 ng/mL) compared with MS (106.9 ng/mL, P = 0.015) and HCs (107.2 ng/mL, P = 0.007). Receiver operating characteristic curve analysis revealed that PECAM-1 (area under the curve (AUC): 0.729) and ICAM-2 (AUC: 0.747) had adequate abilities to distinguish NMOSD from MS, and VCAM-1 (AUC: 0.719), PECAM-1 (area under the curve: 0.743), ICAM-1 (AUC: 0.778), and ICAM-2 (AUC: 0.749) exhibited potential to differentiate NMOSD and HCs. Serum levels of PECAM-1 also demonstrated a negative correlation with Kurtzke Expanded Disability Status Scale scores in patients with NMOSD.

interpretationOur results reveal possible BBB breakdown signals specifically observed in NMOSD and highlight the potential role of cell adhesion molecules as biomarkers of this disease.

Indexed as

AdultArea Under CurveBiomarkersBlood-Brain BarrierFemaleHumansMaleMiddle AgedMultiple SclerosisNeuromyelitis OpticaROC CurveVascular Cell Adhesion Molecule-1BiomarkersVascular Cell Adhesion Molecule-1

Identifiers

PMID32860355
PMCPMC7545585
OpenAlexW3082956890

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.