Evidence map›Paper›PMID 32860348›Full record

ArticleAutism research : official journal of the International Society for Autism Research2020

Sex Differences in Salience Network Connectivity and its Relationship to Sensory Over-Responsivity in Youth with Autism Spectrum Disorder.

Kaitlin K Cummings, Katherine E Lawrence, Leanna M Hernandez, Emily T Wood, Susan Y Bookheimer, Mirella Dapretto, Shulamite A Green

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Centrality of Touch Avoidance in Social Touch Experiences in Autism.Journal of autism and developmental disorders · 2025
    Article
  8. Sensory Processing and Executive Functioning in Autistic Adults.Journal of autism and developmental disorders · 2025
    Article
  9. Validation of the Pain and Sensitivity Reactivity Scale in Neurotypical Late Adolescents and Adults.European journal of investigation in health, psychology and education · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kaitlin K CummingsJane and Terry Semel Institute of Neuroscience and Human Behavior, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-5096-5519
Katherine E LawrenceJane and Terry Semel Institute of Neuroscience and Human Behavior, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-0156-353X
Leanna M HernandezJane and Terry Semel Institute of Neuroscience and Human Behavior, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.
Emily T WoodJane and Terry Semel Institute of Neuroscience and Human Behavior, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.
Susan Y BookheimerJane and Terry Semel Institute of Neuroscience and Human Behavior, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.
Mirella DaprettoJane and Terry Semel Institute of Neuroscience and Human Behavior, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.
Shulamite A GreenJane and Terry Semel Institute of Neuroscience and Human Behavior, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-4248-3576
University of California, Los Angeles · US

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 2007 to 2021
$32.0M
YALE CENTER FOR THE: LEARNING &ATTENTIONP41RR013642 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALL, GARY WILLIAM · 1998 to 2011
$21.9M
Training Grant in Neurobehavioral GeneticsT32NS048004 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, OPHOFF, ROEL A · 2004 to 2025
$5.8M
TRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2M
Mechanisms underlying sensory over-responsivity in ASD and early adversityK08MH112871 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, SHULAMITE ABRA · 2017 to 2020
$798k
Gene-brain-environment interactions as determinants of typical and atypical developmental trajectoriesK00MH119663 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHARMA, LEANNA MARIE HERNANDEZ · 2018 to 2021
$325k
Gene-brain-environment interactions: Predicting social skill heterogeneity in ASDF32MH105167 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, SHULAMITE ABRA · 2014 to 2017
$159k
Impact of Cumulative Genetic Risk on Brain Connectivity in ASDF31MH110140 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAWRENCE, KATHERINE E · 2016 to 2019
$110k
Gene-brain-environment interactions as determinants of typical and atypical developmental trajectoriesF99NS105206 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHARMA, LEANNA MARIE HERNANDEZ · 2017 to 2017
$39k
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR012169 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAZZIOTTA, JOHN C · 1996 to 1997
–
NCRR NIH HHS C06 RR012169NCRR NIH HHS M01 RR000865NCRR NIH HHS P41 RR013642NCRR NIH HHS RR00865NCRR NIH HHS RR12169NCRR NIH HHS RR13642NICHD NIH HHS P50 HD055784NIMH NIH HHS F31 MH110140NIMH NIH HHS F32 MH105167NIMH NIH HHS K00 MH119663NIMH NIH HHS K08 MH112871NIMH NIH HHS R01 MH100028NIMH NIH HHS R01MH100028NIMH NIH HHS T32 MH073517NIMH NIH HHS T32MH073517-12NINDS NIH HHS F99 NS105206NINDS NIH HHS T32 NS048004NINDS NIH HHS T32NS048004
6 · The paper itself

Abstract

Individuals with autism spectrum disorder (ASD) are significantly more likely to experience sensory over-responsivity (SOR) compared to neurotypical controls. SOR in autism has been shown to be related to atypical functional connectivity in the salience network (SN), a brain network thought to help direct attention to the most relevant stimuli in one's environment. However, all studies to date which have examined the neurobiological basis of sensory processing in ASD have used primarily male samples so little is known about sex differences in the neural processing of sensory information. This study examined the relationship between SOR and resting-state functional connectivity in the SN for 37 males and 16 females with autism, ages 8-17 years. While there were no sex differences in parent-rated SOR symptoms, there were significant sex differences in how SOR related to SN connectivity. Relative to females with ASD, males with ASD showed a stronger association between SOR and increased connectivity between the salience and primary sensory networks, suggesting increased allocation to sensory information. Conversely, for females with ASD, SOR was more strongly related to increased connectivity between the SN and prefrontal cortex. Results suggest that the underlying mechanisms of SOR in ASD are sex specific, providing insight into the differences seen in the diagnosis rate and symptom profiles of males and females with ASD. LAY SUMMARY: Sensory over-responsivity (SOR) is common in autism. Most research on the neural basis of SOR has focused on males, so little is known about SOR or its neurobiology in females with autism spectrum disorder. Here despite no sex differences in SOR symptoms, we found sex differences in how SOR related to intrinsic connectivity in a salience detection network. Results show sex differences in the neural mechanisms underlying SOR and inform sex differences seen in diagnosis rates and symptom profiles in autism. Autism Res 2020, 13: 1489-1500. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.

Indexed as

Sex CharacteristicsAdolescentAutism Spectrum DisorderBrainBrain MappingChildFemaleHumansMagnetic Resonance ImagingMaleautism spectrum disorderresting-state fMRIsalience networksensorysex differences

Identifiers

PMID32860348
PMCPMC8351910
OpenAlexW3082489914

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.