ArticleAnnals of clinical and translational neurology2020
Centromedian thalamic responsive neurostimulation for Lennox-Gastaut epilepsy and autism.
Article in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Neurostimulation in children with drug-resistant epilepsy: strategies in subcortical targeting and systematic review of the evidence.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Pooled it
- Responsive neurostimulation in pediatric epilepsy: a systematic review and individual patient meta-analysis supplemented by a single institution case series in 105 aggregated patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Real-world outcomes of responsive neurostimulation in patients with Lennox-Gastaut syndrome: A multicenter retrospective study.Epilepsia open · 2026Observational
- Thalamic interictal epileptic and non-epileptic events during NREM sleep in patients with focal epilepsy: a Stereo-EEG study.EBioMedicine · 2026Article
- Connectivity between the seizure onset zone and the thalamus correlates with seizure outcomes in thalamic responsive neurostimulation.Epilepsia · 2026Article
- Recent Advances in the Management of Seizures in Children.Paediatric drugs · 2026Review
- Non-Pharmacological Treatment Methods of Lennox-Gastaut Syndrome-Review of the Literature.Biomedicines · 2025Review
- Chronic thalamic recordings for idiopathic generalized epilepsy and Lennox-Gastaut syndrome: Ictal and interictal electrophysiological findings.Epilepsia open · 2025Article
- Invasive Neurostimulation for the Treatment of Epilepsy.Seminars in neurology · 2025Review
- The thalamus: Structure, function, and neurotherapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Seizure freedom using a regional approach to responsive neurostimulation for multifocal drug-resistant epilepsy: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- The role of neuromodulation in the management of drug-resistant epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Challenges and future directions of SUDEP models.Lab animal · 2024Review
- Bilateral centromedian nucleus of thalamus responsive neurostimulation for pediatric-onset drug-resistant epilepsy.Epilepsia · 2024Article
- A pediatrician's guide to epilepsy surgery.Current problems in pediatric and adolescent health care · 2024Article
- Neurostimulation treatments for epilepsy: Deep brain stimulation, responsive neurostimulation and vagus nerve stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- The changing landscape of palliative epilepsy surgery for Lennox Gastaut Syndrome.Frontiers in neurology · 2024Review
- The Utility of Responsive Neurostimulation for the Treatment of Pediatric Drug-Resistant Epilepsy.Brain sciences · 2023Review
- Characteristics of ictal thalamic EEG in pediatric-onset neocortical focal epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug-resistant epilepsy secondary to Lennox-Gastaut Syndrome (LGS) and autism spectrum disorder (ASD) treated with the RNS System. Both patients have experienced 75-99% clinical seizure reductions in >1 year of follow-up. We illustrate that children with diffuse onset, multifocal epilepsy, including frontal and thalamic circuits thought to exist in the generation of LGS seizures, can be treated with responsive neurostimulation safely and effectively, targeting thalamic networks, and avoiding palliative disconnections and resections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.