ArticleClinical & experimental ophthalmology2020
Retinal microvasculature impairment in patients with congenital heart disease investigated by optical coherence tomography angiography.
Article in Clinical & experimental ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 26 citations in OpenAlex.
- Retinal and Choroidal Alterations in Heart Failure: A Systematic Review and Meta-analysis of OCT and OCT-A Findings with Emphasis on HFrEF.Ophthalmology and therapy · 2025Review
- Retinal optical coherence tomography angiography (OCTA) biomarkers of cardiovascular disease: a review article.Eye (London, England) · 2025Review
- Early diagnosis of coronary heart disease based on retinal microvascular parameters of OCTA.Frontiers in cell and developmental biology · 2025Article
- Association of preoperative retinal microcirculation and perioperative outcomes in patients undergoing congenital cardiac surgery.Orphanet journal of rare diseases · 2023Observational
- Retinal Vascular Density Change in Patients With Aortic Valve Regurgitation.Cardiology research · 2023Article
- Microvascular and structural analysis of the retina and choroid in heart failure patients with reduced ejection fraction.Scientific reports · 2023Article
- Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic Hypertension.Journal of the American Heart Association · 2022Article
- Ebstein anomaly associated with retinal venular dilatation, migraine, and visual snow syndrome: a case report.BMC ophthalmology · 2022Article
- Early Diagnosis and Treatment of Coronary Heart Disease with Image Features of Optical Coherence Tomography under Adaptive Segmentation Algorithm.Computational and mathematical methods in medicine · 2022Article
- [Optical coherence tomography angiography and cardiovascular diseases. An overview of the current knowledge].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021Review
- The Impact of Chronic Heart Failure on Retinal Vessel Density Assessed by Optical Coherence Tomography Angiography in Children with Dilated Cardiomyopathy.Journal of clinical medicine · 2021Article
- Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart Disease.Frontiers in cardiovascular medicine · 2021Article
- Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography.Frontiers in aging neuroscience · 2021Article
- Retinal microvasculature impairment in patients with congenital heart disease investigated by optical coherence tomography angiography.Clinical & experimental ophthalmology · 2020Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importanceA high prevalence of retinal abnormalities have been reported in congenital heart disease (CHD), but quantitative analysis of retinal vasculature is scarce. Optical coherence tomography angiography (OCTA) is a noninvasive method to quantitatively assess the retinal microvasculature.
backgroundTo investigate the retinal microvasculature changes in CHD patients by using OCTA.
designCross-sectional study.
participantsA total of 158 participants including 57 cyanotic CHD (CCHD) patients, 60 acyanotic CHD (ACHD) patients and 41 control subjects were included.
methodsAll participants underwent a comprehensive ophthalmologic examination, including refraction measurement, intraocular pressure measurement and OCTA.
main outcome measuresVessel density (VD) was measured within the radial peripapillary capillary (RPC), superficial capillary plexus (SCP) and deep capillary plexus (DCP) of the macula.
resultsCCHD patients had significantly lower VD in the RPC, SCP and DCP (all P < .01) compared to control subjects, and significantly lower VD in the RPC and DCP (both P < .05) compared to ACHD patients. Besides, among the CHD group, VD in the RPC was positively correlated with oxygen saturation (whole image, ρ = 0.45; peripapillary, ρ = 0.48) and negatively correlated with haematocrit (whole image, ρ = 0.55; peripapillary, ρ = 0.55) (all P < .001). CONCLUSIONS AND RELEVANCE: Retinal VD might be a surrogate to reflect the effect of chronic systemic hypoxemia in CHD patients. OCTA could be a convenient and noninvasive tool to evaluate the retinal structure and function in CHD patients.
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