Evidence map›Paper›PMID 32860147›Full record

ArticleBioprocess and biosystems engineering2021

Reaction coupling separation for isosteviol production from stevioside catalyzed by acidic ion-exchange resin.

Xueyi Hu, Zhuoyu Zhou, Zongying Zhang, Xiaoxia Wang, Xiaochen Sui, Junming Chen, Yongmei Xia, Jue Zhang, Jianguo Lin

Abstract read
PubMed Publisher
In one paragraph

Article in Bioprocess and biosystems engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xueyi HuState Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu, China.
Zhuoyu ZhouState Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu, China.
Zongying ZhangState Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu, China.
Xiaoxia WangState Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu, China.
Xiaochen SuiState Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu, China.
Junming ChenState Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu, China.
Yongmei XiaState Key Laboratory of Food Science and Technology, School of Chemical and Materials Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu, China. ymxia@jiangnan.edu.cn.
Jue ZhangKey Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu, China.
Jianguo LinKey Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu, China.
Jiangnan University · CNState Key Laboratory of Food Science and Technology · CN

Funding

National Natural Science Foundation of China 31371837National Natural Science Foundation of China 31772017
6 · The paper itself

Abstract

Isosteviol, a prodrug used to be obtained via Wagner-Meerwein rearrangement from steviol with low yield and long reaction time. Herein, an in-situ separation-coupling-reaction is presented to prepare isosteviol from the natural sweetener stevioside. Simply with in-situ water-washing, the product containing 92.98% purity of isosteviol was obtained with a stevioside conversion of 97.23% from a packet bed reactor without further separation. Within the assayed inorganic acid, organic acids and acidic ionic liquids, the acidic ion-exchange resins provided higher product specificity towards isosteviol. Furthermore, comparing to 5-Fluorouracil, the product presented similar and even stronger inhibition on proliferation of the assayed human cancer cells in a time and dose-dependence by causing cell phase arrest. Isosteviol treatment caused G1 arrest on SGC-7901, HCT-8 and HCT-116 cells, S arrest on HepG2, Huh-7 and HepG3B cells, and G2 arrest on MGC-803 cells, respectively. Reaction coupling separation for isosteviol production catalyzed by acidic ion-exchange resin.

Indexed as

Antineoplastic AgentsProdrugsCatalysisDiterpenes, KauraneG2 PhaseGlucosidesHCT116 CellsHep G2 CellsHumansIon Exchange ResinsNeoplasmsAntineoplastic AgentsDiterpenes, KauraneGlucosidesIon Exchange ResinsisosteviolProdrugssteviosideAnticancerCation-exchange resinHydrolysisIonic liquidIsosteviolStevioside

Identifiers

PMID32860147
OpenAlexW3082244044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.