Evidence map›Paper›PMID 32860109›Full record

Trial reportLangenbeck's archives of surgery2020

Antibiotic prophylaxis in acute cholecystectomy revisited: results of a double-blind randomised controlled trial.

Gona Jaafar, Gabriel Sandblom, Lars Lundell, Folke Hammarqvist

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Langenbeck's archives of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02619149 (Piperacllin Versus Placebo in Patients Undergoing Surgery for Acute Cholecystitis), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02619149 phase3completednot on this map

Piperacllin Versus Placebo in Patients Undergoing Surgery for Acute Cholecystitis

TypeinterventionalSponsorKarolinska InstitutetRan2009 to 2018Enrolled100ConditionsCholecystitis, AcuteArmsPiperacillin-tazobactam combination product, Saline solution
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Gona JaafarSubject Trauma Reparative Medicine, CLINTEC, Karolinska University Hospital, 14186, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-8356-2206
Gabriel SandblomDepartment of Clinical Science and Education, Department of Surgery, Södersjukhuset, Karolinska Institute, Stockholm, Sweden. gabriel.sandblom@ki.se.ORCID https://orcid.org/0000-0002-7416-4951
Lars LundellDepartment of Surgery, CLINTEC, Karolinska Institute, Stockholm, Sweden.
Folke HammarqvistSubject Trauma Reparative Medicine, CLINTEC, Karolinska University Hospital, 14186, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-9175-4534
Karolinska University Hospital · SEOdense University Hospital · DK

Funding

Vetenskapsrådet 2018-06926
6 · The paper itself

Abstract

purposeEvidence supporting the value of preoperative antibiotic prophylaxis (PAP) in surgery for acute cholecystitis is lacking. This study aimed to shed light on whether PAP in acute cholecystectomy for cholecystitis reduces the postoperative infectious complication (PIC) rate. Secondary outcomes were the prevalence of bacteriobilia, CRP values and leucocyte counts.

methodsThe study was performed as a single-centre, double-blinded, placebo-controlled, randomised study. Patients with acute cholecystitis amenable for acute laparoscopic cholecystectomy were randomly assigned to either PAP (piperacillin/ tazobactam) or placebo, and the subsequent clinical course was followed.

resultsA total of 106 patients were enrolled, 16 of whom were excluded due to protocol violation. PIC developed in 22 of the 90 patients included with no significant difference between the PAP and placebo groups (8 patients in the PAP group and 14 in the placebo arm, p = 0.193). The PIC rate was significantly higher in patients with a raised CRP at randomisation and on the day of surgery and in cases of conversion to an open procedure (p = 0.008, 0.004 and 0.017, respectively) but with no differences between the study groups.

conclusionPAP does not affect the risk for PIC in patients with acute cholecystitis. The major risk factors determining PIC in these patients need defining, in particular, the impact of bacteriobilia.

trial registrationThe study was registered at clinicaltrials.gov (NCT02619149) December 2, 2015.

Indexed as

Cholecystectomy, LaparoscopicCholecystitisCholecystitis, AcuteAntibiotic ProphylaxisCholecystectomyHumansTreatment OutcomeAcute cholecystitisAntibiotic prophylaxisBacteriobiliaLaparoscopic cholecystectomyPostoperative complicationPostoperative infectious complication

Identifiers

PMID32860109
PMCPMC7686002
OpenAlexW3081870310

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.