SynthesisJournal of neurology2021
Impact of leukoaraiosis severity on the association of outcomes of mechanical thrombectomy for acute ischemic stroke: a systematic review and a meta-analysis.
Synthesis in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Leukoaraiosis severity and outcomes of endovascular thrombectomy for acute ischemic stroke: a systematic review and meta-analysis.European radiology · 2025Pooled it
- The association between the severity and distribution of white matter lesions and hemorrhagic transformation after ischemic stroke: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- White matter lesion effect modification of aspirin and unfractionated heparin during endovascular stroke treatment.Insights into imaging · 2025Article
- A comparative study of risk factors in predictive models for cognitive dysfunction in patients with leukoaraiosis based on machine learning algorithms.Frontiers in neuroscience · 2025Article
- Identifying gut microbiota with high specificity for ischemic stroke with large vessel occlusion.Scientific reports · 2024Article
- Long term for patients with futile endovascular reperfusion after stroke.CNS neuroscience & therapeutics · 2024Article
- Nomogram to predict ventilator-associated pneumonia in large vessel occlusion stroke after endovascular treatment: a retrospective study.Frontiers in neurology · 2024Article
- Impact of leukoaraiosis or blood pressure on clinical outcome, mortality and symptomatic intracerebral hemorrhage after mechanical thrombectomy in acute ischemic stroke.Scientific reports · 2022Article
- Predictors of futile recanalization in patients with acute ischemic stroke undergoing mechanical thrombectomy in late time windows.Frontiers in neurology · 2022Article
- Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke.Scientific reports · 2021Article
- Prognostic Role of Chronic Rhinosinusitis in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy.Journal of clinical medicine · 2021Article
- Stroke care in Italy at the time of the COVID-19 pandemic: a lesson to learn.Journal of neurology · 2021Review
- A rare case of acute motor axonal neuropathy and myelitis related to SARS-CoV-2 infection.Journal of neurology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeukoaraiosis (LA) severity is associated with poor outcome after mechanical thrombectomy (MT) for acute ischemic stroke (AIS) caused by large vessel occlusion. This meta-analysis aimed to assess the association of LA severity with AIS-related risk factors and outcomes of MT.
methodsPubMed, Web of Science, EMBASE, and Cochrane Collaboration Database was searched for studies on MT for AIS with LA. We conducted a random-effects meta-analysis for the prevalence of stroke risk factors and the MT outcome in the absent to moderate LA and severe LA groups.
resultsWe included seven cohort studies involving 1294 participants (1019 with absent to moderate LA and 275 with severe LA). The absent to moderate LA group had a significantly lower prevalence of coronary artery disease (odds ratio [OR] 0.43; 95% CI 0.29-0.66), atrial fibrillation (OR, 0.26; 95% CI 0.17-0.38), hypertension (OR, 0.39; 95% CI 0.24-0.61), and ischemic stroke (OR, 0.27; 95% CI 0.15-0.50) than the severe LA group. There were no significant between-group differences in symptom onset to recanalization time (364.4 versus 356.2 min, mean difference 19.4; 95% CI - 28.3 to 67.2), final recanalization rate (modified thrombolysis in cerebral infarction score of 2b/3; OR, 0.87; 95% CI 0.55-1.38), and symptomatic intracranial hemorrhage (OR, 0.62; 95% CI 0.34-1.11). The absent to moderate LA group had a higher good functional outcome (modified Rankin Scale score of 0-2 at 90 days; OR, 4.55; 95% CI 3.20-6.47) and a lower mortality rate (179/1019 vs 108/275; OR, 0.28; 95% CI 0.20-0.39).
conclusionThere are unique differences in the characteristics of risk factors and clinical outcomes of ischemic stroke across patients with LA of different severity. Patients with severe LA are more likely to be associated with risk factors for cerebrovascular disease and have a poor post-MT outcome.
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