Evidence map›Paper›PMID 32860083›Full record

SynthesisCurrent hypertension reports2020

Efficacy of Probiotics in Patients of Cardiovascular Disease Risk: a Systematic Review and Meta-analysis.

Asher Dixon, Kai Robertson, Amanda Yung, Michael Que, Hayden Randall, Don Wellalagodage, Tynan Cox, Dylan Robertson, Cheng Chi, Jing Sun

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current hypertension reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 11 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 11 syntheses or guidelines pooled it, 106 citations in OpenAlex.

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  11. Impact of Obesity-Induced Inflammation on Cardiovascular Diseases (CVD).International journal of molecular sciences · 2021
    Pooled it
  12. Trial
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  20. A Meta-analysis of Randomized Placebo-controlled Trials on the Effects of Probiotics for Autism Spectrum Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Asher DixonSchool of Medicine, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Q4222, Australia.
Kai RobertsonSchool of Medical Science, Griffith University, Gold Coast, Australia.
Amanda YungSydney Medical School, University of Sydney, Camperdown, NSW, Australia.
Michael QueSydney Medical School, University of Sydney, Camperdown, NSW, Australia.
Hayden RandallSydney Medical School, University of Sydney, Camperdown, NSW, Australia.
Don WellalagodageSydney Medical School, University of Sydney, Camperdown, NSW, Australia.
Tynan CoxSchool of Medicine, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Q4222, Australia.
Dylan RobertsonSchool of Medicine, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Q4222, Australia.
Cheng ChiSchool of Medicine, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Q4222, Australia.
Jing SunSchool of Medicine, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Q4222, Australia. j.sun@griffith.edu.au.
Griffith University · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This meta-analysis examined the effect of probiotics on outcomes associated with cardiovascular disease risk factors (high blood pressure, overweight BMI, high cholesterol and triglycerides, elevated HbA1c and serum glucose). All randomised controlled trials publish on PubMed, Scopus, Embase, Grey Literature and the Cochrane Central Register of Controlled Trials (CENTRAL) from 1990 to 2020 were systematically searched. The PEDro scale was used to assess the quality of studies. A total of 34 studies with 2177 adults were selected for inclusion in the analysis. The mean difference and effect size with a 95% confidence interval (CI) were analysed for the pooled results. Statistically significant pooled effects of probiotics were found in the reduction of systolic and diastolic blood pressure, total cholesterol, LDL-C, serum glucose, HbA1C and BMI; and elevation of HDL-C. No significant changes were observed in the outcome of triglycerides. Subgroup analysis revealed statistically significant effects of probiotics on the treatment of risk factors, with results favouring longer duration of treatment (> 1.5 months), use of alternate formulations (kefir and powder), higher dosage of probiotics (> 1.0 × 10

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2HypertensionProbioticsAdultBlood PressureFemaleHumansCardiovascular DiseaseDiabetesDyslipidaemiaHypertensionNutritionProbiotics

Identifiers

PMID32860083
OpenAlexW3082474860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.