Evidence map›Paper›PMID 32859993›Full record

ArticleCell research2021

Oncogenic AURKA-enhanced N

Fei Peng, Jie Xu, Bai Cui, Qilan Liang, Sai Zeng, Bin He, Hong Zou, Manman Li, Huan Zhao, Yuting Meng and 17 more

Open access · bronzeAbstract read
In one paragraph

Article in Cell research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 150 citations in OpenAlex.

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  12. Targeting "don't eat me" signal: breast cancer immunotherapy.Breast cancer research and treatment · 2025
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  13. RNA mCell investigation · 2025
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  14. IMPlications of IMP2 in RNA Biology and Disease.International journal of molecular sciences · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. [Characteristics of Aurora Kinase A-Mediated Tumor Microenvironment in Colorectal Cancer and Mining of Active Compounds From Chinese Herbs].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
  19. Emerging Role of the DREAM Complex in Cancer and Therapeutic Opportunities.International journal of molecular sciences · 2025
    Review
  20. Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 5 institutions in 2 countries.

Fei Peng *Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Jie Xu *Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China. xujie@dmu.edu.cn.
Bai Cui *Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Qilan Liang *Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Sai Zeng *Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Bin He *State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
Hong ZouInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Manman LiInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Huan ZhaoInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Yuting MengInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Jin ChenKey Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian, Liaoning, 116023, China.
Bing LiuInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Shasha LvInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Peng ChuInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Fan AnInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Zifeng WangState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.ORCID http://orcid.org/0000-0001-7400-5224
Junxiu HuangInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Yajing ZhanInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Yuwei LiaoInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Jinxin LuInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Lingzhi XuDepartment of Oncology, the Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116023, China.
Jin ZhangThe 3rd Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment and Research Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, Tianjin, 300060, China.
Zhaolin SunInstitute of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, 116044, China.
Zhiguang LiInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China.
Fangjun WangKey Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian, Liaoning, 116023, China.
Eric W-F LamDepartment of Surgery and Cancer, Imperial College London, London, W12 0NN, UK.ORCID http://orcid.org/0000-0003-1274-3576
Quentin LiuInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, China. liuq9@mail.sysu.edu.cn.
Dalian Medical University · CNSun Yat-sen University · CNDalian Institute of Chemical Physics · CNImperial College London · GBTianjin Medical University Cancer Institute and Hospital · CN

Funding

Cancer Research UK C37/18784Cancer Research UK C37/A12011Medical Research Council MR/N012097/1
6 · The paper itself

Abstract

RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms. Here, we demonstrate that DROSHA interacts with β-Catenin to transactivate STC1 in an RNA cleavage-independent manner, contributing to breast cancer stem-like cell (BCSC) properties. DROSHA mRNA stability is enhanced by N

Indexed as

Transcriptional ActivationAdenosineAdultAgedAnimalsAurora Kinase ABreast NeoplasmsFemaleGlycoproteinsHEK293 CellsHumansMCF-7 CellsMiceMice, Inbred BALB CMice, NudeMiddle AgedAdenosineAURKA protein, humanAurora Kinase ADROSHA protein, humanGlycoproteinsN-methyladenosineOncogene ProteinsRibonuclease IIIteleocalcin

Identifiers

PMID32859993
PMCPMC8027457
OpenAlexW3082869881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.