ArticleCommunications biology2020
Multiple ancestral haplotypes harboring regulatory mutations cumulatively contribute to a QTL affecting chicken growth traits.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Integrated Analysis of SNPs and Structural Variations via High-depth Whole-genome Sequencing Reveals the Genetic Architecture and Optimizes Genomic Prediction in Chickens.Poultry science · 2026Article
- Identification of candidate genes and regulatory mechanisms for thick shank phenotype of Dong Tao chickens.Poultry science · 2026Article
- The impact of haplotypes derived from Chinese pigs on genetic variation and economic traits in the Duroc breed.Genetics, selection, evolution : GSE · 2025Article
- Clade specific divergence, cumulative haplo-pheno analysis, and genomic prediction of cytokinin oxidase (CKX) gene family under drought stress in rice.Plant molecular biology · 2025Article
- Mapping the regulatory genetic landscape of complex traits using a chicken advanced intercross line.Nature communications · 2025Article
- Article
- Integrating metabolomics for precision nutrition in poultry: optimizing growth, feed efficiency, and health.Frontiers in veterinary science · 2025Review
- Mapping quantitative trait loci regions associated with Marek's disease on chicken autosomes by means of selective DNA pooling.Scientific reports · 2024Article
- Haplotype analysis incorporating ancestral origins identified novel genetic loci associated with chicken body weight using an advanced intercross line.Genetics, selection, evolution : GSE · 2024Article
- Non-Targeted Metabolomics of Serum Reveals Biomarkers Associated with Body Weight in Wumeng Black-Bone Chickens.Animals : an open access journal from MDPI · 2024Article
- Article
- Phenotypic divergence between broiler and layer chicken lines is regulated at the molecular level during development.BMC genomics · 2024Article
- The main genetic locus associated with the evolution of gamecocks is centered on ISPD.G3 (Bethesda, Md.) · 2024Article
- Whole-genome variants dataset of 209 local chickens from China.Scientific data · 2024Article
- Genomic prediction based on selective linkage disequilibrium pruning of low-coverage whole-genome sequence variants in a pure Duroc population.Genetics, selection, evolution : GSE · 2023Article
- Genetic structure and characteristics of Tibetan chickens.Poultry science · 2023Article
- Serum metabolic profile and metabolome genome-wide association study in chicken.Journal of animal science and biotechnology · 2023Article
- An atlas of regulatory elements in chicken: A resource for chicken genetics and genomics.Science advances · 2023Article
- Chicken chromatin accessibility atlas accelerates epigenetic annotation of birds and gene fine-mapping associated with growth traits.Zoological research · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In depth studies of quantitative trait loci (QTL) can provide insights to the genetic architectures of complex traits. A major effect QTL at the distal end of chicken chromosome 1 has been associated with growth traits in multiple populations. This locus was fine-mapped in a fifteen-generation chicken advanced intercross population including 1119 birds and explored in further detail using 222 sequenced genomes from 10 high/low body weight chicken stocks. We detected this QTL that, in total, contributed 14.4% of the genetic variance for growth. Further, nine mosaic precise intervals (Kb level) which contain ancestral regulatory variants were fine-mapped and we chose one of them to demonstrate the key regulatory role in the duodenum. This is the first study to break down the detail genetic architectures for the well-known QTL in chicken and provides a good example of the fine-mapping of various of quantitative traits in any species.
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