Evidence map›Paper›PMID 32859965›Full record

ArticleCommunications biology2020

Diversity in the intrinsic apoptosis pathway of nematodes.

Neil D Young, Tiffany J Harris, Marco Evangelista, Sharon Tran, Merridee A Wouters, Tatiana P Soares da Costa, Nadia J Kershaw, Robin B Gasser, Brian J Smith, Erinna F Lee and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Neil D YoungFaculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0001-8756-229X
Tiffany J HarrisOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.
Marco EvangelistaOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.
Sharon TranOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.
Merridee A WoutersOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.ORCID http://orcid.org/0000-0002-2121-912X
Tatiana P Soares da CostaLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.
Nadia J KershawThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Robin B GasserFaculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0002-4423-1690
Brian J SmithLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.ORCID http://orcid.org/0000-0003-0498-1910
Erinna F Lee *Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia. Erinna.Lee@latrobe.edu.au.ORCID http://orcid.org/0000-0003-1255-9808
W Douglas Fairlie *Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia. doug.fairlie@onjcri.org.au.ORCID http://orcid.org/0000-0002-2498-1160
La Trobe University · AUOlivia Newton-John Cancer Wellness & Research Centre · AUThe University of Melbourne · AUThe University of Sydney · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, subsequent studies showed C. elegans apoptosis has several unique features compared with human apoptosis. To date, there has been no detailed analysis of apoptosis regulators in nematodes other than C. elegans. Here, we discovered BCL-2 orthologues in 89 free-living and parasitic nematode taxa representing four evolutionary clades (I, III, IV and V). Unlike in C. elegans, 15 species possess multiple (two to five) BCL-2-like proteins, and some do not have any recognisable BCL-2 sequences. Functional studies provided no evidence that BAX/BAK proteins have evolved in nematodes, and structural studies of a BCL-2 protein from the basal clade I revealed it lacks a functionally important feature of the C. elegans orthologue. Clade I CED-4/APAF-1 proteins also possess WD40-repeat sequences associated with apoptosome assembly, not present in C. elegans, or other nematode taxa studied.

Indexed as

ApoptosisSignal TransductionAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGenes, HelminthMicePhylogenyProtein DomainsProtein Structure, SecondaryProto-Oncogene Proteins c-bcl-2Caenorhabditis elegans ProteinsProto-Oncogene Proteins c-bcl-2

Identifiers

PMID32859965
PMCPMC7456325
OpenAlexW3082923171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.