ArticleNature communications2020
Intracellular sodium elevation reprograms cardiac metabolism.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
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Who cites it
47 citing papers in PubMed, 83 citations in OpenAlex.
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- Sodium-myo-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice.Cardiovascular research · 2026Article
- Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy.Nature cardiovascular research · 2026Article
- Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model.The Journal of physiology · 2026Review
- Metabolomics-constrained modelling reveals dominant oxidative metabolism in the Egyptian fruit bat myocardium.PloS one · 2026Article
- Sodium disrupts mitochondrial energy metabolism to execute NECSO.Nature communications · 2025Article
- Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes.Scientific reports · 2025Article
- Bat power-metabolic profiling of the Egyptian fruit batbioRxiv : the preprint server for biology · 2025Article
- Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model.European heart journal · 2025Article
- Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets.Nature reviews. Cardiology · 2025Review
- Mechano-energetic uncoupling in heart failure.Nature reviews. Cardiology · 2025Review
- Interferon gamma signaling drives cardiac metabolic rewiring.bioRxiv : the preprint server for biology · 2025Article
- Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotype.Cardiovascular diabetology · 2025Article
- Mineralocorticoid receptor phase separation modulates cardiac preservation.Nature cardiovascular research · 2025Article
- Article
- Sodium-glucose exchanger 2 inhibitor canagliflozin promotes mitochondrial metabolism and alleviates salt-induced cardiac hypertrophy via preserving SIRT3 expression.Journal of advanced research · 2025Article
- Intersection of Immunology and Metabolism in Myocardial Disease.Circulation research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Dunja AksentijevićSchool of Cardiovascular and Medical Sciences, British Heart Foundation Centre of Research Excellence, King's College London, The Rayne Institute, St Thomas' Hospital, London, UK.ORCID http://orcid.org/0000-0002-8480-6727
Anja KarlstaedtDepartment of Internal Medicine, Division of Cardiology, McGovern Medical School The University of Texas Health Science Center at Houston, Houston, TX77030, USA.ORCID http://orcid.org/0000-0001-5689-3571
Marina V BasalaySchool of Cardiovascular and Medical Sciences, British Heart Foundation Centre of Research Excellence, King's College London, The Rayne Institute, St Thomas' Hospital, London, UK.ORCID http://orcid.org/0000-0001-5608-3878
Brett A O'BrienSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.ORCID http://orcid.org/0000-0003-2997-3669
David Sanchez-TataySchool of Cardiovascular and Medical Sciences, British Heart Foundation Centre of Research Excellence, King's College London, The Rayne Institute, St Thomas' Hospital, London, UK.ORCID http://orcid.org/0000-0003-2834-2937
Seda EminagaSchool of Cardiovascular and Medical Sciences, British Heart Foundation Centre of Research Excellence, King's College London, The Rayne Institute, St Thomas' Hospital, London, UK.
Alpesh ThakkerInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Daniel A TennantInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0003-0499-2732
William FullerInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.ORCID http://orcid.org/0000-0002-5883-4433
Thomas R EykynSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.ORCID http://orcid.org/0000-0003-1768-3808
Heinrich TaegtmeyerDepartment of Internal Medicine, Division of Cardiology, McGovern Medical School The University of Texas Health Science Center at Houston, Houston, TX77030, USA.ORCID http://orcid.org/0000-0002-5434-6360
Michael J ShattockSchool of Cardiovascular and Medical Sciences, British Heart Foundation Centre of Research Excellence, King's College London, The Rayne Institute, St Thomas' Hospital, London, UK. michael.shattock@kcl.ac.uk.ORCID http://orcid.org/0000-0001-6242-7585
St Thomas' Hospital · GBThe University of Texas Health Science Center at Houston · USUniversity of Birmingham · GBUniversity of Glasgow · GB
Funding
SWITCHING OF METABOLIC GENES IN UNLOADED HEARTR01HL061483 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TAEGTMEYER, HEINRICH · 1999 to 2021
$6.2MMetabolic Rewiring of the Heart Through Reductive CarboxylationR00HL141702 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI KARLSTAEDT, ANJA · 2021 to 2023
$747kMetabolic Rewiring of the Heart Through Reductive CarboxylationK99HL141702 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARLSTAEDT, ANJA · 2019 to 2021
$285kBritish Heart Foundation FS/16/21/31860British Heart Foundation RE/08/003British Heart Foundation RG/12/4/29426British Heart Foundation RG/17/15/33106Cancer Research UK C1060/A10334Department of HealthMedical Research CouncilNHLBI NIH HHS K99 HL141702NHLBI NIH HHS R00 HL141702NHLBI NIH HHS R01 HL061483Wellcome TrustWellcome Trust 088641/Z/09/Z
Abstract
Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute (75 μM ouabain 100 nM blebbistatin) or chronic myocardial Na
Indexed as
AnimalsCellular ReprogrammingCytoplasmDisease Models, AnimalEnergy MetabolismGene Knock-In TechniquesHeartHeart FailureHypertrophyIsolated Heart PreparationMaleMetabolic DiseasesMiceMice, Inbred C57BLMice, KnockoutMitochondria7-chloro-5-(2-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-oneSodiumSodium-Calcium ExchangerThiazepines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.