Evidence map›Paper›PMID 32859868›Full record

ArticleAsian journal of andrology

Mutational analysis of the

Xu Zhang, Tai-Jian Zhang, Wen Liu, Yun-Na Ning, Yue-Hong Bian, Yong-Zhi Cao, Hong-Bin Liu, Jin-Long Ma, Hao-Bo Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xu ZhangCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Tai-Jian ZhangCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Wen LiuCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Yun-Na NingCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Yue-Hong BianCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Yong-Zhi CaoCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Hong-Bin LiuCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Jin-Long MaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Hao-Bo ZhangCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a crucial transcription factor for spermatogenesis, GATA-binding protein 4 (GATA4) plays important roles in the functioning of Sertoli and Leydig cells. Conditional knockout of GATA4 in mice results in age-dependent testicular atrophy and loss of fertility. However, whether GATA4 is associated with human azoospermia has not been reported. Herein, we analyzed the GATA4 gene by direct sequencing of samples obtained from 184 Chinese men with idiopathic nonobstructive azoospermia (NOA). We identified a missense mutation (c.191G>A, p.G64E), nine single-nucleotide polymorphisms (SNPs), and one rare variant (c.

Indexed as

AdultAsian PeopleAzoospermiaChinaClaudinsDNA Mutational AnalysisGATA4 Transcription FactorHumansMaleMutation, MissensePhosphoproteinsPolymorphism, Single NucleotideSteroidogenic Acute Regulatory ProteinTranscriptional ActivationClaudinsCLDN11 protein, humanGATA4 protein, humanGATA4 Transcription FactorPhosphoproteinsSteroidogenic Acute Regulatory Proteinbiological functionGATA-binding protein 4 (GATA4)mutationnonobstructive azoospermia

Identifiers

PMID32859868
PMCPMC7991814
OpenAlexW3082501171

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.