Evidence map›Paper›PMID 32859726›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

IL-21 Promotes Intestinal Memory IgA Responses.

Xiangsheng Huang, Wenjing Yang, Suxia Yao, Anthony J Bilotta, Yao Lu, Zheng Zhou, Pawan Kumar, Sara M Dann, Yingzi Cong

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Journal of microbiology and biotechnology · 2025
    Pooled it
  2. Review
  3. Article
  4. CD4Trends in immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiangsheng HuangDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555.
Wenjing YangDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555.ORCID 0000-0003-1541-1892
Suxia YaoDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555.
Anthony J BilottaDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555.
Yao LuDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555.
Zheng ZhouDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555.ORCID 0000-0002-0390-9135
Pawan KumarDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794.
Sara M DannDepartment of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555; and.ORCID 0000-0002-6893-2838
Yingzi CongDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555; yicong@utmb.edu.ORCID 0000-0003-4167-7395
The University of Texas Medical Branch at Galveston · USStony Brook School · US

Funding

STING signaling in T cells regulation of intestinal homeostasis and inflammatorybowel diseasesR01DK124132 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2020 to 2024
$2.5M
Th17-IgA Axis in Regulation of Intestinal InflammationR01DK105585 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2016 to 2020
$1.8M
GPR120 regulation of inflammatory bowel diseaseR01DK125011 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2020 to 2022
$1.5M
Microbiota metabolites, GPR, and inflammatory bowel diseasesR01DK112436 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2017 to 2020
$1.4M
GPR120 regulation of intestinal IgA responses and gut IgA-coated bacteriaR21AI150210 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUN, JIAREN · 2020 to 2021
$435k
NIAID NIH HHS R21 AI150210NIDDK NIH HHS R01 DK105585NIDDK NIH HHS R01 DK112436NIDDK NIH HHS R01 DK124132NIDDK NIH HHS R01 DK125011
6 · The paper itself

Abstract

The role of IL-21, produced mainly by Th17 cells and T follicular helper cells, has been intensively investigated in B cell differentiation and Ab class switch. However, how IL-21 regulates memory IgA

Indexed as

AnimalsB-LymphocytesCells, CulturedCitrobacter rodentiumEnterobacteriaceae InfectionsImmunoglobulin AImmunoglobulin Class SwitchingImmunologic MemoryInterleukin-21InterleukinsIntestinal MucosaMiceMice, Inbred C57BLMice, KnockoutReceptors, Interleukin-21Th17 CellsImmunoglobulin AInterleukin-21InterleukinsReceptors, Interleukin-21

Identifiers

PMID32859726
PMCPMC7898419
OpenAlexW3082776643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.