ArticleeNeuro
Regional Activity in the Rat Anterior Cingulate Cortex and Insula during Persistence and Quitting in a Physical-Effort Task.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Reconfiguration of Behavioral Signals in the Anterior Cingulate Cortex Based on Emotional State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control.Nature communications · 2023Article
- Highly unstable heterogeneous representations in VIP interneurons of the anterior cingulate cortex.Molecular psychiatry · 2022Article
- Functional Interactions Between the Parafascicular Thalamic Nucleus and Motor Cortex Are Altered in Hemiparkinsonian Rat.Frontiers in aging neuroscience · 2022Article
- The role of anterior insula-brainstem projections and alpha-1 noradrenergic receptors for compulsion-like and alcohol-only drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Prior Cocaine Exposure Increases Firing to Immediate Reward While Attenuating Cue and Context Signals Related to Reward Value in the Insula.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Stimulation in the Rat Anterior Insula and Anterior Cingulate During an Effortful Weightlifting Task.Frontiers in neuroscience · 2021Article
- Roles of Motor Cortex Neuron Classes in Reach-Related Modulation for Hemiparkinsonian Rats.Frontiers in neuroscience · 2021Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As animals carry out behaviors, particularly costly ones, they must constantly assess whether or not to persist in the behavior or quit. The anterior cingulate cortex (ACC) has been shown to assess the value of behaviors and to be especially sensitive to physical effort costs. Complimentary to these functions, the insula is thought to represent the internal state of the animal including factors such as hunger, thirst, and fatigue. Using a novel weight-lifting task for rats, we characterized the local field potential (LFP) activity of the ACC and anterior insula (AI) during effort expenditure. In the task, male rats are challenged to work for sucrose reward, which costs progressively more effort over time to obtain. Rats are able to quit the task at any point. We found modest shifts in LFP theta (7-9 Hz) activity as the task got progressively more difficult in terms of absolute effort expenditure. However, when the LFP data were analyzed based on the relative progress of the rat toward quitting the task, substantial shifts in LFP power in the theta and gamma (55-100 Hz) frequency bands were observed in ACC and AI. Both ACC and AI theta power decreased as the rats got closer to quitting, while ACC and AI gamma power increased. Furthermore, coherency between ACC and AI in the delta (2-4 Hz) range shifted alongside the performance state of the rat. Overall, we show that ACC and AI LFP activity changes correlate to the relative performance state of rats in an effort-based task.
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