ArticleeNeuro
OpenVape: An Open-Source E-Cigarette Vapor Exposure Device for Rodents.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Context-dependent attention and memory outcomes resulting from combined prenatal THC and nicotine exposure following chronic stress.Pharmacology, biochemistry, and behavior · 2026Article
- In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely moving behavior.Lab animal · 2026Article
- Early life nicotine vapor exposure increases nicotine vapor seeking in adult male rats.Psychopharmacology · 2026Article
- Acute nicotine vapor attenuates sensorimotor gating deficits in HIV-1 transgenic rats.Psychopharmacology · 2025Article
- Characterization of a novel oronasal-restricted nicotine vaping self-administration model in mice.Neuropharmacology · 2025Article
- Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options.Pharmacology, biochemistry, and behavior · 2024Review
- Acute nicotine vapor normalizes sensorimotor gating and reduces locomotor activity deficits in HIV-1 transgenic rats.bioRxiv : the preprint server for biology · 2024Article
- Behavioral and Pharmacokinetic Assessment of Nicotine e-Cigarette Inhalation in Female Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Rats chasing the dragon: A new heroin inhalation method.Journal of neuroscience methods · 2024Article
- Article
- A Simple, Lightweight, and Low-Cost Customizable Multielectrode Array for Local Field Potential Recordings.eNeuro · 2023Article
- Beyond the label: current evidence and future directions for the interrelationship between electronic cigarettes and mental health.Frontiers in psychiatry · 2023Review
- The long-term effects of repeated heroin vapor inhalation during adolescence on measures of nociception and anxiety-like behavior in adult Wistar rats.Psychopharmacology · 2022Article
- Reinforcing effects of fentanyl and sufentanil aerosol puffs in rats.Psychopharmacology · 2022Article
- Alcohol and Vaporized Nicotine Co-exposure During Adolescence Contribute Differentially to Sex-Specific Behavioral Effects in Adulthood.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- Effects of combined THC and heroin vapor inhalation in rats.Psychopharmacology · 2022Article
- Sex and age differences in approach behavior toward a port that delivers nicotine vapor.Journal of the experimental analysis of behavior · 2022Article
- Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence.Current neuropharmacology · 2022Review
- Sex Differences in the Behavioural Outcomes of Prenatal Nicotine and Tobacco Exposure.Frontiers in neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of "vaping" has recently seen significant increases in North America, especially in adolescents. However, the behavioral correlates of vaping are largely unexplored. The uptake of existing technologies meant for rodent vapor inhalation remains limited because of a lack of affordability and versatility (ability to be used with a variety of vaporizers). The OpenVape (OV) offers an open-source, low-cost solution that can be used in a variety of research contexts. Here, we present a specific use case, combining the OV apparatus with JUUL e-cigarettes. This apparatus consists of Arduino-operated vacuum pumps that deliver vapor directly from e-cigarettes to exposure chambers. The OV is easy to build and customize for any type of vaporizer (e.g., nicotine pod or tank; cannabis flower or concentrates). To test the OV, we performed biochemical verification and behavioral studies. The behavioral test (conditioned place preference, CPP) was conducted using adolescent and adult animals to assess developmental differences in the rewarding effects of nicotine vapor, as previously observed with injected nicotine. These findings demonstrate that even after brief exposures to nicotine vapor, pharmacologically relevant nicotine and cotinine levels could be detected in plasma, and significant CPP was observed, especially in adolescent rats which showed preference at shorter puff delivery durations (lower nicotine doses) compared with adults. Together, these findings suggest that OV provides an affordable, open-source option for preclinical behavioral research into the effects of vaping.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.