Evidence map›Paper›PMID 32859711›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

First-in-Human Assessment of

Mika Naganawa, Nabeel Nabulsi, Shannan Henry, David Matuskey, Shu-Fei Lin, Lawrence Slieker, Adam J Schwarz, Nancy Kant, Cynthia Jesudason, Kevin Ruley and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Review
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  9. Lower Muscarinic MBiological psychiatry · 2026
    Article
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  12. Article
  13. Article
  14. "Pseudo-reference-based Input Function Shape" (pRef-IFS): Towards a True image-derived input function for PET kinetic modeling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. An Interactive Brain Atlas of Knowledge.bioRxiv : the preprint server for biology · 2026
    Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Mika NaganawaPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and mika.naganawa@yale.edu.
Nabeel NabulsiPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.
Shannan HenryPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.
David MatuskeyPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.
Shu-Fei LinPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.
Lawrence SliekerEli Lilly and Company, Indianapolis, Indiana.
Adam J SchwarzEli Lilly and Company, Indianapolis, Indiana.
Nancy KantEli Lilly and Company, Indianapolis, Indiana.
Cynthia JesudasonEli Lilly and Company, Indianapolis, Indiana.
Kevin RuleyEli Lilly and Company, Indianapolis, Indiana.
Antonio NavarroEli Lilly and Company, Indianapolis, Indiana.
Hong GaoPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.
Jim RopchanPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.
David LabareePET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.
Richard E CarsonPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.
Yiyun HuangPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.
Yale University · USEli Lilly (United States) · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
NCATS NIH HHS UL1 TR001863NCRR NIH HHS UL1 RR024139
6 · The paper itself

Abstract

This was a first-in-human study of the PET radiotracer

Indexed as

AdultBrainFemaleHumansIndolesKineticsLigandsMalePiperidinesPositron-Emission TomographyRadioactive TracersRadiochemistryReceptor, Muscarinic M1SafetyIndolesLigandsLSN3172176PiperidinesRadioactive TracersReceptor, Muscarinic M1brain imagingmuscarinic acetylcholine receptor 1PETscopolaminetest–retest reproducibility

Identifiers

PMID32859711
PMCPMC8049371
OpenAlexW3081519314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.