Evidence map›Paper›PMID 32859708›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with

Mark G MacAskill, Agne Stadulyte, Lewis Williams, Timaeus E F Morgan, Nikki L Sloan, Carlos J Alcaide-Corral, Tashfeen Walton, Catriona Wimberley, Chris-Anne McKenzie, Nick Spath and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
  2. Cardiovascular imaging with total-body PET.The British journal of radiology · 2026
    Review
  3. Article
  4. Review
  5. Network-Based Analysis for the Quantification of Brain and Body Immune Axes with Total-Body PET Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  6. First human whole-body biodistribution and dosimetry analysis of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Longitudinal [European journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Development and evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  17. Article
  18. Article
  19. Preclinical characterization of [Acta pharmacologica Sinica · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Mark G MacAskillUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Agne StadulyteUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Lewis WilliamsSchool of Chemistry, WestCHEM, University of Glasgow, Glasgow, United Kingdom.
Timaeus E F MorganSchool of Chemistry, WestCHEM, University of Glasgow, Glasgow, United Kingdom.
Nikki L SloanSchool of Chemistry, WestCHEM, University of Glasgow, Glasgow, United Kingdom.
Carlos J Alcaide-CorralUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Tashfeen WaltonUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Catriona WimberleyEdinburgh Imaging, University of Edinburgh, Edinburgh, United Kingdom.
Chris-Anne McKenzieMRC Edinburgh Brain Tissue Bank, University of Edinburgh, Edinburgh, United Kingdom.
Nick SpathUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
William MungallBioresearch and Veterinary Services, University of Edinburgh, Edinburgh, United Kingdom.
Ralph BouHaidarForensic Pathology, University of Edinburgh, Edinburgh, United Kingdom.
Marc R DweckUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Gillian A GrayUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
David E NewbyUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Christophe LucatelliEdinburgh Imaging, University of Edinburgh, Edinburgh, United Kingdom.
Andrew SutherlandSchool of Chemistry, WestCHEM, University of Glasgow, Glasgow, United Kingdom.
Sally L PimlottSchool of Medicine, University of Glasgow, Glasgow, United Kingdom; and.
Adriana A S TavaresUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom adriana.tavares@ed.ac.uk.
University of Edinburgh · GBUniversity of Glasgow · GBNHS Greater Glasgow and Clyde · GB

Funding

British Heart Foundation CH/09/002British Heart Foundation CH/09/002/26360British Heart Foundation FS/14/78/31020British Heart Foundation FS/19/34/34354British Heart Foundation PG/16/12/32022British Heart Foundation PG/17/83/33370British Heart Foundation RE/13/3/30183British Heart Foundation RE/18/5/34216British Heart Foundation RG/16/10/32375Medical Research Council G0701127Wellcome Trust WT103782AIA
6 · The paper itself

Abstract

Myocardial infarction (MI) is one of the leading causes of death worldwide, and inflammation is central to tissue response and patient outcomes. The 18-kDa translocator protein (TSPO) has been used in PET as an inflammatory biomarker. The aims of this study were to screen novel, fluorinated, TSPO radiotracers for susceptibility to the rs6971 genetic polymorphism using in vitro competition binding assays in human brain and heart; assess whether the in vivo characteristics of our lead radiotracer,

Indexed as

Polymorphism, Single NucleotidePositron Emission Tomography Computed TomographyAnimalsFluorine RadioisotopesInflammationMacrophagesMaleMyocardial InfarctionRadioactive TracersRatsRats, Sprague-DawleyReceptors, GABAFluorine-18Fluorine RadioisotopesRadioactive TracersReceptors, GABATSPO protein, humaninflammationmacrophagemyocardial infarctionPETTSPO

Identifiers

PMID32859708
PMCPMC8049364
OpenAlexW3082286879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.