Evidence map›Paper›PMID 32859697›Full record

ArticleDisease models & mechanisms2020

The SDHB Arg230His mutation causing familial paraganglioma alters glycolysis in a new

Éva Saskői, Zoltán Hujber, Gábor Nyírő, István Likó, Barbara Mátyási, Gábor Petővári, Katalin Mészáros, Attila L Kovács, László Patthy, Shreyas Supekar and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. TheInternational journal of molecular sciences · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Comprehensive Genetic Study of Malignant Cervical Paraganglioma.International journal of molecular sciences · 2023
    Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Éva SaskőiDepartment of Biological Anthropology, Eötvös Lorand University, Budapest H-1117, Hungary.
Zoltán Hujber1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest H-1085, Hungary.ORCID 0000-0002-9790-8044
Gábor NyírőHAS-SE Momentum Hereditary Endocrine Tumour Syndromes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest H-1089, Hungary.
István LikóHAS-SE Momentum Hereditary Endocrine Tumour Syndromes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest H-1089, Hungary.
Barbara MátyásiDepartment of Biological Anthropology, Eötvös Lorand University, Budapest H-1117, Hungary.
Gábor Petővári1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest H-1085, Hungary.
Katalin MészárosHAS-SE Momentum Hereditary Endocrine Tumour Syndromes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest H-1089, Hungary.
Attila L KovácsDepartment of Anatomy, Cell and Developmental Biology, Eötvös Lorand University, Budapest H-1117, Hungary.
László PatthyInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest H-1117, Hungary.
Shreyas SupekarBioinformatics Institute, Agency for Science, Technology and Research, 138671 Singapore.
Hao FanBioinformatics Institute, Agency for Science, Technology and Research, 138671 Singapore.
Gergely SvábDepartment of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, Budapest H-1094, Hungary.
László TretterDepartment of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, Budapest H-1094, Hungary.
Arunabh SarkarLaboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology, CSIR-Central Drug Research Institute, Lucknow 226031, India.ORCID 0000-0002-3881-5710
Aamir NazirLaboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Anna Sebestyén1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest H-1085, Hungary.
Attila PatócsHAS-SE Momentum Hereditary Endocrine Tumour Syndromes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest H-1089, Hungary.
Anil MehtaDivision of Medical Sciences, Ninewells Hospital Medical School, University of Dundee, Dundee DD1 1NH, UK.
Krisztina Takács-VellaiDepartment of Biological Anthropology, Eötvös Lorand University, Budapest H-1117, Hungary krisztina.takacs@ttk.elte.hu.ORCID 0000-0002-4472-0363
Semmelweis University · HUEötvös Loránd University · HUAgency for Science, Technology and Research · SGCentral Drug Research Institute · INInstitute of Molecular Life Sciences · HUUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The conserved B-subunit of succinate dehydrogenase (SDH) participates in the tricarboxylic acid cycle (TCA) cycle and mitochondrial electron transport. The Arg230His mutation in SDHB causes heritable pheochromocytoma/paraganglioma (PPGL). In

Indexed as

Adenosine TriphosphateAmino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCitric Acid CycleConserved SequenceDisease Models, AnimalGene Expression ProfilingGlycolysisHumansIron-Sulfur ProteinsL-Lactate DehydrogenaseMitochondriaMitochondrial ProteinsMutationAdenosine TriphosphateCaenorhabditis elegans ProteinsIron-Sulfur ProteinsL-Lactate DehydrogenaseMitochondrial ProteinsProtein Subunitssdhb-1 protein, C elegansSDHB protein, humanSuccinate DehydrogenaseCancerC. elegansFamilial paraganglioma syndromeSuccinate dehydrogenaseTCA cycleWarburg-like glycolysis

Identifiers

PMID32859697
PMCPMC7578352
OpenAlexW3082534389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.