Evidence map›Paper›PMID 32859642›Full record

Observational studyCancer genomics & proteomics

Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of

Deise Cibele N DE Almeida, Michel Platini Caldas DE Souza, Carolina Koury Nassar Amorim, Jersey Heitor DA Silva MauÉs, Fernanda DO E Santo Sagica, Caroline Aquino Moreira-Nunes, Edivaldo Herculano C DE Oliveira

Open access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Deise Cibele N DE AlmeidaNeuroscience and Cell Biology Pos-Graduation Program, ICB, UFPA, Belém, PA, Brazil.
Michel Platini Caldas DE SouzaCenter of Technological Innovation, Evandro Chagas Institute, Ananindeua, PA, Brazil.
Carolina Koury Nassar AmorimLaboratory of Tissue Culture and Cytogenetics, SAMAM, Instituto Evandro Chagas, Ananindeua, PA, Brazil.
Jersey Heitor DA Silva MauÉsLaboratory of Human Cytogenetics, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Fernanda DO E Santo SagicaLaboratory of Tissue Culture and Cytogenetics, SAMAM, Instituto Evandro Chagas, Ananindeua, PA, Brazil.
Caroline Aquino Moreira-NunesPharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil carolfam@gmail.com.
Edivaldo Herculano C DE OliveiraLaboratory of Tissue Culture and Cytogenetics, SAMAM, Instituto Evandro Chagas, Ananindeua, PA, Brazil.
Instituto Evandro Chagas · BRUniversidade Federal do Pará · BRUniversidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microarray-based analysis in two groups of patients (<45 and ≥45 years old), in order to verify the occurrence of specific copy number alterations (CNAs) that could be associated to different patient behaviors associated with age. PATIENTS AND

methodsIn order to search and compare genomic alterations that may be related to age, we evaluated the occurrence of CNAs in the genome of 24 PTC samples, divided in two groups (<45 and ≥45 years old).

resultsWe identified only one region showing a statistically significant difference between the groups (p=0.00357): a deletion of approximately 537 kps in 1p35.3., which was more frequent in patients aged 45 years or older. This is the region where, among others, the gene SESN2 is located, which is activated under oxidative stress and plays an antioxidant role, in addition to protecting the genetic material from damage generated by reactive oxygen species (ROS).

conclusionThis is the first time that a CNA involving the deletion of the SESN2 gene is associated with papillary thyroid carcinomas, particularly in patients aged 45 years and older, indicating that this deletion would lead to a more malignant and prominent tumoral behavior associated to a worst prognosis.

Indexed as

Genetic Predisposition to DiseaseAdolescentAdultAgedAge FactorsAgingBiomarkers, TumorDisease ProgressionDNA Copy Number VariationsDNA DamageFemaleGene DeletionHumansMaleMiddle AgedNuclear ProteinsBiomarkers, TumorNuclear ProteinsSESN2 protein, humanSestrinsaCGHdeletionPapillary thyroid cancersenescenceSESN2

Identifiers

PMID32859642
PMCPMC7472442
OpenAlexW3082625193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.