Evidence map›Paper›PMID 32859635›Full record

Observational studyCancer genomics & proteomics

The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk.

Li-Hsiou Chen, Te-Chun Shen, Chia-Hsiang Li, Kuo-Liang Chiu, Yu-Chen Hsiau, Yun-Chi Wang, Chi-Li Gong, Zhi-Hong Wang, Wen-Shin Chang, Chia-Wen Tsai and 2 more

Open access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Does Molecular Profiling ofCurrent oncology (Toronto, Ont.) · 2022
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Li-Hsiou ChenGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Te-Chun ShenGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Chia-Hsiang LiGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Kuo-Liang ChiuGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Yu-Chen HsiauTerry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Yun-Chi WangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Chi-Li GongDepartment of Physiology, China Medical University, Taichung, Taiwan, R.O.C.
Zhi-Hong WangDepartment of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.
Wen-Shin ChangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Chia-Wen TsaiGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Te-Chun HsiaTerry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
DA-Tian BauGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com.
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe study aims to evaluate the contribution of excision repair cross-complementing group 1 (ERCC1), which plays an important role in genome integrity maintenance, to lung cancer risk. MATERIALS AND

methodsERCC1 rs11615 and rs3212986 genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism analysis and their association with lung cancer risk was examined among 358 lung cancer patients and 716 controls.

resultsThe proportions of CC, CT and TT for the rs11615 genotype were 43.6%, 41.6% and 14.8% in the case group and 50.0%, 41.1% and 8.9% in the control group, respectively (p for trend=0.0082). Allelic analysis showed that ERCC1 rs11615 T-allele carriers have a 1.32-fold higher risk of lung cancer than wild-type C-allele carriers [95%confidence interval (CI)=1.09-1.60, p=0.0039]. In addition, a significant interaction between the rs11615 genotype and smoking status was observed.

conclusionThe T allele of ERCC1 rs11615 jointly with smoking habits may contribute to a higher lung cancer risk in Taiwan.

Indexed as

Genetic Predisposition to DiseaseAgedAllelesCase-Control StudiesCigarette SmokingConfounding Factors, EpidemiologicDNA-Binding ProteinsDNA RepairEndonucleasesFemaleGenotypeHumansLung NeoplasmsMaleMiddle AgedPolymorphism, Single NucleotideDNA-Binding ProteinsEndonucleasesERCC1 protein, humanERCC1genotypelung cancerpolymorphismsmokingTaiwan

Identifiers

PMID32859635
PMCPMC7472448
OpenAlexW3082721652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.