Evidence map›Paper›PMID 32859582›Full record

ArticleDevelopment (Cambridge, England)2020

Pinhead signaling regulates mesoderm heterogeneity via the FGF receptor-dependent pathway.

Olga Ossipova, Keiji Itoh, Aurelian Radu, Jerome Ezan, Sergei Y Sokol

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Olga OssipovaDepartment of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA sergei.sokol@mssm.edu olga.ossipova@mssm.edu.ORCID 0000-0001-9402-6057
Keiji ItohDepartment of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Aurelian RaduDepartment of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jerome EzanDepartment of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sergei Y SokolDepartment of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA sergei.sokol@mssm.edu olga.ossipova@mssm.edu.ORCID 0000-0002-3963-9202
Icahn School of Medicine at Mount Sinai · US

Funding

Extracellular regulation of Xenopus developmentR01HD092990 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Sergei Sokol · 2018 to 2026
$3.2M
Mechanisms of neural crest specificationR01DE027665 · NIDCR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SOKOL, SERGEI · 2018 to 2022
$2.3M
NICHD NIH HHS R01 HD092990NIDCR NIH HHS R01 DE027665
6 · The paper itself

Abstract

Among the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The mesoderm is specified by secreted signaling proteins from the FGF, Nodal, BMP and Wnt families. No new classes of extracellular mesoderm-inducing factors have been identified in more than two decades. Here, we show that the

Indexed as

Wnt Signaling PathwayAnimalsMesodermReceptors, Fibroblast Growth FactorRNA-SeqTransforming Growth Factor betaXenopus laevisXenopus ProteinsNODAL protein, XenopusReceptors, Fibroblast Growth FactorTransforming Growth Factor betaXenopus ProteinsAktAntero-posterior axisBrachyuryErk1FGFNodalWntXenopus

Identifiers

PMID32859582
PMCPMC7502591
OpenAlexW3082374285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.