Evidence map›Paper›PMID 32859154›Full record

ArticleBMC cardiovascular disorders2020

Plasma trimethylamine n-oxide is associated with renal function in patients with heart failure with preserved ejection fraction.

Fei Guo, Xueting Qiu, Zhirong Tan, Zhenyu Li, Dongsheng Ouyang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  7. Role of Gut Microbiota in Diabetic HFpEF: Mechanisms and Therapeutic Implications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Fei GuoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China.
Xueting QiuDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China.
Zhirong TanDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China.
Zhenyu LiDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China. liyu1552@csu.edu.cn.
Dongsheng OuyangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China. 801940@csu.edu.cn.ORCID 0000-0002-1743-8610
Central South University · CN

Funding

Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples 2017TP1037National Development of Key Novel Drugs for Special Projects of China 2017ZX09304014Natural Science Foundation of Hunan Province 2019JJ50966
6 · The paper itself

Abstract

backgroundHeart failure with preserved ejection fraction (HFpEF) is an emerging global health problem with less awareness. Renal dysfunction in HFpEF is associated with worse outcome. However, there is lack of rapid, noninvasive and accurate method for risk stratification in HFpEF and renal dysfunction. This study aimed to explore the utility of plasma trimethylamine n-oxide (TMAO) for evaluation of HFpEF and renal function.

methodsPlasma TMAO levels were measured in total 324 subjects comprising 228 HFpEF patients and 96 healthy controls.

resultsTMAO levels were significantly elevated in patients with HFpEF compared with controls (12.65(9.32-18.66) μg/l vs 10.85(6.35-15.58) μg/l, p <  0.01). Subjects in higher TMAO tertile group had more incidences of HFpEF ((78.5%) in tertile 3 vs (73.39%) in tertile 2 vs (59.26%) in tertile 1, p <  0.01). TMAO concentrations were inversely correlated with estimated glomerular filtration rate (eGFR) and HFpEF patients with impaired renal function (eGFR < 60 ml/min/1.73 m

conclusionIn this cross-sectional study, HFpEF and renal function were closely related with plasma TMAO levels and TMAO may serve as a diagnostic biomarker for HFpEF and renal function.

Indexed as

Glomerular Filtration RateStroke VolumeVentricular Function, LeftBiomarkersCross-Sectional StudiesFemaleHeart FailureHumansKidneyKidney DiseasesMaleMethylaminesMiddle AgedRetrospective StudiesBiomarkersMethylaminestrimethyloxamineBiomarkereGFRHFpEFRenal dysfunctionTMAO

Identifiers

PMID32859154
PMCPMC7456383
OpenAlexW3082918995

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.