Evidence map›Paper›PMID 32859127›Full record

ArticleInternational journal of molecular sciences2020

Hwei Ling Tan, Yi Bing Zeng, Ee Sin Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hwei Ling TanDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Yi Bing ZengDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Ee Sin ChenDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
National University of Singapore · SGNational University Health System · SG

Funding

Ministry of Education - Singapore MOE2018-T2-1-100Ministry of Education - Singapore R-183-000-404-114
6 · The paper itself

Abstract

Centromere integrity underlies an essential framework for precise chromosome segregation and epigenetic inheritance. Although centromeric DNA sequences vary among different organisms, all eukaryotic centromeres comprise a centromere-specific histone H3 variant, centromeric protein A (CENP-A), on which other centromeric proteins assemble into the kinetochore complex. This complex connects chromosomes to mitotic spindle microtubules to ensure accurate partitioning of the genome into daughter cells. Overexpression of CENP-A is associated with many cancers and is correlated with its mistargeting, forming extra-centromeric kinetochore structures. The mislocalization of CENP-A can be counteracted by proteolysis. The amino (

Indexed as

Binding SitesCell Cycle ProteinsChromosomal Proteins, Non-HistoneHeterochromatinHistone-Lysine N-MethyltransferaseMutationNuclear ProteinsProtein BindingProtein DomainsProtein StabilitySchizosaccharomycesSchizosaccharomyces pombe ProteinsCell Cycle ProteinsChromosomal Proteins, Non-Histoneclr4 protein, S pombeCnp1 protein, S pombeHeterochromatinHistone-Lysine N-MethyltransferaseNuclear ProteinsSchizosaccharomyces pombe ProteinsSim3 protein, S pombeCENP-Acentromerechromosome segregationfission yeastN-terminusprotein turnover

Identifiers

PMID32859127
PMCPMC7503380
OpenAlexW3080324711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.