Evidence map›Paper›PMID 32859030›Full record

ArticleGenes2020

Transcriptome Analysis Reveals Inhibitory Effects of Lentogenic Newcastle Disease Virus on Cell Survival and Immune Function in Spleen of Commercial Layer Chicks.

Jibin Zhang, Michael G Kaiser, Rodrigo A Gallardo, Terra R Kelly, Jack C M Dekkers, Huaijun Zhou, Susan J Lamont

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jibin ZhangDepartment of Animal Science, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0003-3099-6665
Michael G KaiserDepartment of Animal Science, Iowa State University, Ames, IA 50011, USA.
Rodrigo A GallardoPopulation Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Terra R KellyOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Jack C M DekkersDepartment of Animal Science, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0003-4727-8256
Huaijun ZhouDepartment of Animal Science, University of California, Davis, CA 95616, USA.ORCID 0000-0001-6023-9521
Susan J LamontDepartment of Animal Science, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0003-3974-4050
Iowa State University · USUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a major infectious disease in chickens, Newcastle disease virus (NDV) causes considerable economic losses in the poultry industry, especially in developing countries where there is limited access to effective vaccination. Therefore, enhancing resistance to the virus in commercial chickens through breeding is a promising way to promote poultry production. In this study, we investigated gene expression changes at 2 and 6 days post inoculation (dpi) at day 21 with a lentogenic NDV in a commercial egg-laying chicken hybrid using RNA sequencing analysis. By comparing NDV-challenged and non-challenged groups, 526 differentially expressed genes (DEGs) (false discovery rate (FDR) < 0.05) were identified at 2 dpi, and only 36 at 6 dpi. For the DEGs at 2 dpi, Ingenuity Pathway Analysis predicted inhibition of multiple signaling pathways in response to NDV that regulate immune cell development and activity, neurogenesis, and angiogenesis. Up-regulation of interferon induced protein with tetratricopeptide repeats 5 (

Indexed as

TranscriptomeAnimalsCell SurvivalChickensNewcastle DiseaseNewcastle disease virusPoultry DiseasesQuantitative Trait LociSpleenchickengene expressionimmune responseNewcastle diseaseRNA-seqspleen

Identifiers

PMID32859030
PMCPMC7565929
OpenAlexW3081325082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.