Evidence map›Paper›PMID 32859024›Full record

ArticleInternational journal of molecular sciences2020

A De novo Peptide from a High Throughput Peptide Library Blocks Myosin A -MTIP Complex Formation in

Zill E Anam, Nishant Joshi, Sakshi Gupta, Preeti Yadav, Ayushi Chaurasiya, Amandeep Kaur Kahlon, Shikha Kaushik, Manoj Munde, Anand Ranganathan, Shailja Singh

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. TargetingiScience · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Pathogen induced subversion of NADCell death discovery · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zill E AnamSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Nishant JoshiDepartment of Life Sciences, School of Natural Sciences, Shiv Nadar University, Greater Noida, Uttar Pradesh 201304, India.ORCID 0000-0001-7312-6112
Sakshi GuptaSchool of Physical Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Preeti YadavSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Ayushi ChaurasiyaSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Amandeep Kaur KahlonSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Shikha KaushikSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Manoj MundeSchool of Physical Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Anand RanganathanSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Shailja SinghSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Jawaharlal Nehru University · INShiv Nadar University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apicomplexan parasites, through their motor machinery, produce the required propulsive force critical for host cell-entry. The conserved components of this so-called glideosome machinery are myosin A and myosin A Tail Interacting Protein (MTIP). MTIP tethers myosin A to the inner membrane complex of the parasite through 20 amino acid-long C-terminal end of myosin A that makes direct contacts with MTIP, allowing the invasion of

Indexed as

Amino Acid MotifsAntimalarialsBinding SitesDrug Evaluation, PreclinicalErythrocytesHigh-Throughput Screening AssaysHumansMembrane ProteinsModels, MolecularMultiprotein ComplexesNonmuscle Myosin Type IIAPeptide LibraryPeptidesPlasmodium falciparumProtein BindingProtozoan ProteinsAntimalarialsMembrane ProteinsMultiprotein ComplexesNonmuscle Myosin Type IIAPeptide LibraryPeptidesProtozoan Proteinsmalariamyosin Amyosin A tail interacting protein (MTIP)peptide inhibitor

Identifiers

PMID32859024
PMCPMC7503848
OpenAlexW3080410362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.