ArticleInternational journal of environmental research and public health2020
Myocardial Injury and Overload among Amateur Marathoners as Indicated by Changes in Concentrations of Cardiovascular Biomarkers.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The Effect of a Single Bout of Exercise to Volitional Exhaustion Under Moderate Normobaric Hypoxia on the Kinetics of Cardiac Biomarkers in Trained and Untrained Men.International journal of molecular sciences · 2026Article
- Early Cardiac Responses to Half-Marathon Running in Amateur Athletes: Implications for Cardiovascular Health and Safe Exercise Participation.Journal of functional morphology and kinesiology · 2026Article
- When the heart cannot keep pace: case report of acute myocarditis in a recreational marathon runner.European heart journal. Case reports · 2026Article
- Acute effects of marathon running on the heart: a systematic review and meta-analysis.BMJ open sport & exercise medicine · 2026Article
- Plasma cardiovascular stress biomarkers response to marathon running.Sports medicine and health science · 2025Article
- Galectin-3 in Cardiovascular Health: A Narrative Review Based on Life's Essential 8 and Life's Simple 7 Frameworks.Current issues in molecular biology · 2025Review
- Physiology and Pathophysiology of Marathon Running: A narrative Review.Sports medicine - open · 2025Review
- Morphological, functional and biochemical differences in cardiac adaptation to endurance exercise among male and female amateur marathon runners.Frontiers in physiology · 2025Article
- Differences in cardiac adaptation to exercise in male and female athletes assessed by noninvasive techniques: a state-of-the-art review.American journal of physiology. Heart and circulatory physiology · 2024Review
- Personality of marathon runners: a narrative review of recent findings.EXCLI journal · 2024Review
- The Effects of Omega-3 Fatty Acid Supplementation on the Lipid Profile and Cardiovascular Markers Following Downhill Running in Long-Distance Runners.Journal of human kinetics · 2023Article
- Circulating Gal-3 and sST2 are associated with acute exercise-induced sustained endothelial activation: Possible relevance for fibrosis development?Experimental physiology · 2023Article
- Moderate- and High-Intensity Endurance Training Alleviate Diabetes-Induced Cardiac Dysfunction in Rats.Nutrients · 2023Article
- Marathon-Induced Cardiac Fatigue: A Review over the Last Decade for the Preservation of the Athletes' Health.International journal of environmental research and public health · 2021Review
- Diagnosis, Investigation and Management of Patients with Acute and Chronic Myocardial Injury.Journal of clinical medicine · 2021Review
- Post-marathon Decline in Right Ventricular Radial Motion Component Among Amateur Sportsmen.Frontiers in physiology · 2021Article
- Remote Ischemic Preconditioning Reduces Marathon-Induced Oxidative Stress and Decreases Liver and Heart Injury Markers in the Serum.Frontiers in physiology · 2021Article
- Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners.Frontiers in physiology · 2020Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marathons continue to grow in popularity among amateurs. However, the impact of intensive exercise on the amateur's cardiovascular system has not yet been studied. Analysis of the influence of the marathon on kinetics of biomarkers reflecting cardiac injury and overload may bring new insights into this issue. We investigated the effect of running a marathon on the concentrations of high sensitivity cardiac troponin I (hs-cTnI), heart-type fatty acid binding protein (H-FABP), N-terminal proatrial natriuretic peptide (NT-proANP), B-type natriuretic peptide (BNP), growth differentiation factor 15 (GDF-15) and galectin 3 (Gal-3) in the population of male amateur runners. The study included 35 amateur marathoners and followed 3 stages: S1-two weeks prior to the marathon, S2-at the finish line and S3-two weeks after. Blood samples were collected at each stage and analyzed for biomarkers and laboratory parameters. Concentrations of all studied biomarkers were significantly higher at S2, whereas at S3 did not differ significantly compared to S1. Running a marathon by an amateur causes an acute rise in biomarkers of cardiac injury and stress. Whether repetitive bouts of intensive exercise elicit long-term adverse cardiovascular effects in amateur marathoners needs further research.
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