Evidence map›Paper›PMID 32858901›Full record

ReviewInternational journal of molecular sciences2020

T Cell Immunity to Bacterial Pathogens: Mechanisms of Immune Control and Bacterial Evasion.

Freya R Shepherd, James E McLaren

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. T Cell Thoughts.Immunological reviews · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
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  14. Review
  15. Article
  16. Article
  17. Article
  18. Pathogens (Basel, Switzerland) · 2025
    Review
  19. Article
  20. Biotechnologia · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Freya R ShepherdDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
James E McLarenDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.ORCID 0000-0002-7021-5934

Funding

Wellcome Trust 217096/Z/19/ZWelsh Government (Sêr Cymru) unknown
6 · The paper itself

Abstract

The human body frequently encounters harmful bacterial pathogens and employs immune defense mechanisms designed to counteract such pathogenic assault. In the adaptive immune system, major histocompatibility complex (MHC)-restricted αβ T cells, along with unconventional αβ or γδ T cells, respond to bacterial antigens to orchestrate persisting protective immune responses and generate immunological memory. Research in the past ten years accelerated our knowledge of how T cells recognize bacterial antigens and how many bacterial species have evolved mechanisms to evade host antimicrobial immune responses. Such escape mechanisms act to corrupt the crosstalk between innate and adaptive immunity, potentially tipping the balance of host immune responses toward pathological rather than protective. This review examines the latest developments in our knowledge of how T cell immunity responds to bacterial pathogens and evaluates some of the mechanisms that pathogenic bacteria use to evade such T cell immunosurveillance, to promote virulence and survival in the host.

Indexed as

Adaptive ImmunityAnimalsAntigens, BacterialBacteriaHumansImmune EvasionImmunity, InnateT-LymphocytesAntigens, Bacterialbacterial infectionHuman Leukocyte Antigen allelesimmune evasionMAIT cellsmajor histocompatibility complex-restricted T cellssuperantigensT cell immunityvirulenceαβ T cellsγδ T cells

Identifiers

PMID32858901
PMCPMC7504484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.