Evidence map›Paper›PMID 32858886›Full record

ArticleInternational journal of molecular sciences2020

Conventional Co-Housing Modulates Murine Gut Microbiota and Hematopoietic Gene Expression.

Jichun Chen, Shuling Zhang, Xingmin Feng, Zhijie Wu, Wendy Dubois, Vishal Thovarai, Sonia Ahluwalia, Shouguo Gao, Jinguo Chen, Tyler Peat and 4 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. Article
  7. Oral Administration ofMicroorganisms · 2023
    Article
  8. Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Jichun ChenHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Shuling ZhangLaboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Xingmin FengHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Zhijie WuHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Wendy DuboisLaboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Vishal ThovaraiBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Sonia AhluwaliaBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Shouguo GaoHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jinguo ChenCenter for Human Immunology and Autoimmunity, National Institutes of Health, Bethesda, MD 20892, USA.
Tyler PeatLaboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Shurjo K SenBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Giorgio TrinchieriCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Neal S YoungHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Beverly A MockLaboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
National Institutes of Health · USFrederick National Laboratory for Cancer Research · USNational Heart Lung and Blood Institute · US

Funding

NIH HHS NHLBI Intramural Research Program
6 · The paper itself

Abstract

Specific-pathogen-free (SPF) mice have improved hematopoietic characteristics relative to germ-free mice, however, it is not clear whether improvements in hematopoietic traits will continue when the level of microorganism exposure is further increased. We co-housed SPF C57BL/6 mice in a conventional facility (CVT) and found a significant increase in gut microbiota diversity along with increased levels of myeloid cells and T cells, especially effector memory T cells. Through single cell RNA sequencing of sorted KL (c-Kit

Indexed as

HematopoiesisAnimalsBacteriaBone Marrow TransplantationGastrointestinal MicrobiomeGene Expression ProfilingGene Expression RegulationHousing, AnimalLymphocyte ActivationMiceMice, Inbred C57BLMyeloid CellsPhylogenySequence Analysis, RNASingle-Cell AnalysisSpecific Pathogen-Free Organismsconventional co-housinggut microbiotahematopoietic stem and progenitor cellsmicesingle cell RNA-seqspecific pathogen free

Identifiers

PMID32858886
PMCPMC7503692
OpenAlexW3081488542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.