Evidence map›Paper›PMID 32858858›Full record

ArticleBrain sciences2020

Autonomic Changes in Juvenile-Onset Huntington's Disease.

Jordan L Schultz, Peg C Nopoulos

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Systemic Symptoms in Huntington's Disease: A Comprehensive Review.Movement disorders clinical practice · 2024
    Pooled it
  2. Observational
  3. Autonomic dysfunction in neurodegenerative disease.Nature reviews. Neuroscience · 2025
    Review
  4. Review
  5. Clinical Review of Juvenile Huntington's Disease.Journal of Huntington's disease · 2024
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jordan L SchultzDepartment of Psychiatry, Carver College of Medicine at the University of Iowa, Iowa City, IA 52242, USA.
Peg C NopoulosDepartment of Psychiatry, Carver College of Medicine at the University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-8810-1903
University of Iowa · US

Funding

Longitudinal Assessment of Brain Structure and Function in Juvenile Onset Huntington's DiseaseU01NS055903 · NINDS · UNIVERSITY OF IOWA · PI NOPOULOS, PEGGY C · 2019 to 2025
$17.4M
Growth and Development of the Striatum in Huntington's DiseaseR01NS055903 · NINDS · UNIVERSITY OF IOWA · PI PEGGY C NOPOULOS · 2009 to 2026
$5.0M
NINDS NIH HHS R01 NS055903NINDS NIH HHS R01NS055903NINDS NIH HHS U01 NS055903
6 · The paper itself

Abstract

Patients with adult-onset Huntington's Disease (AOHD) have been found to have dysfunction of the autonomic nervous system that is thought to be secondary to neurodegeneration causing dysfunction of the brain-heart axis. However, this relationship has not been investigated in patients with juvenile-onset HD (JOHD). The aim of this study was to compare simple physiologic measures between patients with JOHD (

Indexed as

autonomicjuvenile-onset Huntington’s Diseaseneurodegeneration

Identifiers

PMID32858858
PMCPMC7563896
OpenAlexW3080818790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.