ArticleComputer methods and programs in biomedicine2020
WU-NEAT: A clinically validated, open-source MATLAB toolbox for limited-channel neonatal EEG analysis.
Article in Computer methods and programs in biomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Data-driven wavelet coherence approach to assess neurovascular coupling in neonatal hypoxic-ischemic encephalopathy.Neurophotonics · 2026Article
- A Pilot Study on Dynamic Multimodal Neuromonitoring for Predicting Neurodevelopmental Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy.Developmental neuroscience · 2026Article
- Real-time monitoring of wavelet-based neurovascular coupling in neonates with hypoxic ischemic encephalopathy using an hourly time window.Neurophotonics · 2025Article
- EEG Spectral Power and Neurovascular Coupling as Early Predictors of Neurodevelopmental Outcome in Neonatal Hypoxic-Ischemic Encephalopathy.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Analysis of electrode performance on amplitude integrated electroencephalography in neonates: evaluation of a new electrode aCUP-E vs. liquid gel electrodes.Frontiers in pediatrics · 2024Article
- Evaluation of neurovascular coupling during neuroprotective therapies: A single site HEAL ancillary study.Early human development · 2023Article
- Low frequency power in cerebral blood flow is a biomarker of neurologic injury in the acute period after cardiac arrest.Resuscitation · 2022Article
- Article
- Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG.Scientific reports · 2021Article
- Current Status and Future Directions of Neuromonitoring With Emerging Technologies in Neonatal Care.Frontiers in pediatrics · 2021Review
- Wavelet-based neurovascular coupling can predict brain abnormalities in neonatal encephalopathy.NeuroImage. Clinical · 2021Article
- Rigor of Neurovascular Coupling (NVC) Assessment in Newborns Using Different Amplitude EEG Algorithms.Scientific reports · 2020Article
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6 authors.
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Abstract
backgroundLimited-channel EEG research in neonates is hindered by lack of open, accessible analytic tools. To overcome this limitation, we have created the Washington University-Neonatal EEG Analysis Toolbox (WU-NEAT), containing two of the most commonly used tools, provided in an open-source, clinically-validated package running within MATLAB.
methodsThe first algorithm is the amplitude-integrated EEG (aEEG), which is generated by filtering, rectifying and time-compressing the original EEG recording, with subsequent semi-logarithmic display. The second algorithm is the spectral edge frequency (SEF), calculated as the critical frequency below which a user-defined proportion of the EEG spectral power is located. The aEEG algorithm was validated by three experienced reviewers. Reviewers evaluated aEEG recordings of fourteen preterm/term infants, displayed twice in random order, once using a reference algorithm and again using the WU-NEAT aEEG algorithm. Using standard methodology, reviewers assigned a background pattern classification. Inter/intra-rater reliability was assessed. For the SEF, calculations were made using the same fourteen recordings, first with the reference and then with the WU-NEAT algorithm. Results were compared using Pearson's correlation coefficient.
resultsFor the aEEG algorithm, intra- and inter-rater reliability was 100% and 98%, respectively. For the SEF, the mean±SD Pearson correlation coefficient between algorithms was 0.96±0.04.
conclusionWe have demonstrated a clinically-validated toolbox for generating the aEEG as well as calculating the SEF from EEG data. Open-source access will enable widespread use of common analytic algorithms which are device-independent and unlikely to become outdated as technology changes, thereby facilitating future collaborative research in neonatal EEG.
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