Evidence map›Paper›PMID 32858141›Full record

ArticleNeuroscience2020

Topical Application of Loperamide/Oxymorphindole, Mu and Delta Opioid Receptor Agonists, Reduces Sensitization of C-fiber Nociceptors that Possess Na

Megan L Uhelski, Daniel Bruce, Rebecca Speltz, George L Wilcox, Donald A Simone

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Central Nervous System Distribution of an Opioid Agonist Combination with Synergistic Activity.The Journal of pharmacology and experimental therapeutics · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Megan L UhelskiDepartment of Diagnostic & Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA.
Daniel BruceDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Rebecca SpeltzDepartment of Diagnostic & Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
George L WilcoxDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Dermatology, University of Minnesota, Minneapolis, MN 55455, USA.
Donald A SimoneDepartment of Diagnostic & Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: simon003@umn.edu.
University of Minnesota · US

Funding

Neural Mechanisms of Cancer PainR01CA241627 · NCI · UNIVERSITY OF MINNESOTA · PI SIMONE, DONALD · 2019 to 2023
$1.9M
NCI NIH HHS R01 CA241627
6 · The paper itself

Abstract

It was recently shown that local injection, systemic administration or topical application of the peripherally-restricted mu-opioid receptor (MOR) agonist loperamide (Lo) and the delta-opioid receptor (DOR) agonist oxymorphindole (OMI) synergized to produce highly potent anti-hyperalgesia that was dependent on both MOR and DOR located in the periphery. We assessed peripheral mechanisms by which this Lo/OMI combination produces analgesia in mice expressing the light-sensitive protein channelrhodopsin2 (ChR2) in neurons that express Na

Indexed as

LoperamideNociceptorsAnimalsHyperalgesiaInflammationMiceMorpholinesNerve Fibers, UnmyelinatedReceptors, Opioid, deltaReceptors, Opioid, muLoperamideMorpholinesoxymorphindoleReceptors, Opioid, deltaReceptors, Opioid, muantinociceptonelectrophysiologyhyperalgesianociceptor sensitizationopioids

Identifiers

PMID32858141
PMCPMC7532699
OpenAlexW3080518966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.