Evidence map›Paper›PMID 32858051›Full record

ArticleContraception2020

Comparison of plasma etonogestrel concentrations sampled from the contralateral-to-implant and ipsilateral-to-implant arms of contraceptive implant users.

Alida M Gertz, Ian J Bishop, Boikhutso Simon, Kwana Lechiile, Opelo Badubi, Aamirah Mussa, Carolyn L Westhoff, Chelsea Morroni

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Contraception, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Alida M GertzBotswana-University of Pennsylvania Partnership, University of Botswana Main, Campus 244G - Room 103, Gaborone, Botswana; Afya Bora Consortium Fellowship Program, United States; Botswana Harvard Partnership, Private Bag BO 320, Gaborone, Botswana.
Ian J BishopColumbia University Medical Center, 622 West 168th Street, New York, NY 10032, United States.
Boikhutso SimonBotswana Harvard Partnership, Private Bag BO 320, Gaborone, Botswana.
Kwana LechiileBotswana-University of Pennsylvania Partnership, University of Botswana Main, Campus 244G - Room 103, Gaborone, Botswana.
Opelo BadubiBotswana Harvard Partnership, Private Bag BO 320, Gaborone, Botswana.
Aamirah MussaBotswana Harvard Partnership, Private Bag BO 320, Gaborone, Botswana.
Carolyn L WesthoffColumbia University Medical Center, 622 West 168th Street, New York, NY 10032, United States.
Chelsea MorroniBotswana-University of Pennsylvania Partnership, University of Botswana Main, Campus 244G - Room 103, Gaborone, Botswana; Botswana Harvard Partnership, Private Bag BO 320, Gaborone, Botswana; Liverpool School of Tropical Medicine, Pembroke Pl, Liverpool L3 5QA, United Kingdom. Electronic address: chelsea.morroni@lstmed.ac.uk.
Botswana Harvard AIDS Institute Partnership · BWUniversity of Botswana · BWColumbia University Irving Medical Center · US

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Partnership for Global Health Research Training Program (Renewal)-Supplement for OBSSR, NCI, NCI-AIDS and NIDCDD43TW010543 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, DAVIDSON HOWES HAMER · 2017 to 2026
$12.1M
FIC NIH HHS D43 TW010543NCATS NIH HHS UL1 TR000040
6 · The paper itself

Abstract

objectiveTo compare plasma etonogestrel concentrations sampled from the contralateral- versus ipsilateral-to-implant arm. STUDY

designSub-analysis of a cross-sectional study in Botswana in 33 participants who provided contralateral and ipsilateral blood samples.

resultsPlasma etonogestrel concentrations in contralateral and ipsilateral specimens were highly correlated (correlation coefficient = 0.99; p < 0.0001). Bland-Altman analysis of agreement showed that etonogestrel levels were on average 5.9 pg/mL higher (2.1%) in ipsilateral compared to contralateral specimens (95% confidence interval: -4.1, 15.9 pg/mL).

conclusionsWe found no meaningful differences in plasma etonogestrel concentrations between samples taken from the contralateral- versus ipsilateral-to-implant arm. IMPLICATIONS: Our data suggest that etonogestrel plasma concentrations are unlikely to be meaningfully different between samples drawn from the ipsilateral- versus the contralateral-to-implant arms in etonogestrel contraceptive implant users.

Indexed as

ArmBotswanaContraceptive Agents, FemaleCross-Sectional StudiesDesogestrelDrug ImplantsFemaleHumansContraceptive Agents, FemaleDesogestrelDrug ImplantsetonogestrelContraceptive implantContralateral armEtonogestrelIpsilateral armPharmacokinetics

Identifiers

PMID32858051
PMCPMC8232040
OpenAlexW3081309338

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.