Evidence map›Paper›PMID 32858027›Full record

ArticleAmerican journal of ophthalmology2021

The Michigan Retinal Degeneration Questionnaire: A Patient-Reported Outcome Instrument for Inherited Retinal Degenerations.

Gabrielle D Lacy, Maria Fernanda Abalem, Chris A Andrews, Lilia T Popova, Erin P Santos, Gina Yu, Hanan Y Rakine, Natasha Baig, Joshua R Ehrlich, Abigail T Fahim and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Gene Editing forThe New England journal of medicine · 2024
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  18. Observational
  19. Functional Vision in Patients With Biallelic USH2A Variants.American journal of ophthalmology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Gabrielle D LacyKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Maria Fernanda AbalemKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Ophthalmology and Otolaryngology, University of Sao Paulo Medical School, São Paulo, Brazil.
Chris A AndrewsKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Lilia T PopovaKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Erin P SantosKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Gina YuKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Hanan Y RakineKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Natasha BaigKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Joshua R EhrlichKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Abigail T FahimKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Kari H BranhamKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Joan A StelmackDepartment of Low Vision Service, Illinois Eye and Ear Infirmary, University of Illinois College of Medicine, Chicago, Illinois, USA.
Bonnielin K SwenorWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gislin DagnelieWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
David C MuschKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
K Thiran JayasunderaKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: thiran@umich.edu.

Funding

Michigan Vision Clinician Scientist Development ProgramK12EY022299 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Abigail Fahim, DAVID N ZACKS · 2013 to 2026
$6.3M
NRSA Training CoreTL1TR002242 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLINSTAT, MICHAEL ALLAN · 2017 to 2021
$2.8M
Targeted functional testing for retinal diseases based on patient reported outcomesK23EY026985 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAYASUNDERA, KANISHKA THIRAN · 2016 to 2020
$1.2M
Addressing Low Vision due to Severe Peripheral Field Loss: Development and Validation of a Patient-Centered Outcome MeasureK23EY027848 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EHRLICH, JOSHUA ROBERT · 2017 to 2021
$1.2M
NCATS NIH HHS TL1 TR002242NEI NIH HHS K12 EY022299NEI NIH HHS K23 EY026985NEI NIH HHS K23 EY027848
6 · The paper itself

Abstract

purposeTo create a psychometrically validated patient-reported outcome measure for inherited retinal degenerations.

designQualitative and quantitative patient-reported outcome (PROs) questionnaire development using item response theory validation.

methodsOne hundred twenty-eight patients with a diagnosis of an inherited retinal degeneration at the Kellogg Eye Center (University of Michigan) were recruited and administered a 166-item questionnaire comprising 7 expert-defined domains. The questionnaire was re-administered 4-16 days later to a subset of 25 participants to assess test-retest variability. Graded response models were fit by Cai's Metropolis-Hastings Robbins-Monro algorithm using the R (version 3.6.3) package mirt. Model data were fit to assess questionnaire dimensionality, to estimate item information, and to score participants. Poorly functioning items were removed, and the model was refit to create the final questionnaire.

resultsThe psychometrically validated PROs measure was reduced to a 59-item questionnaire measuring 7 unidimesnional domains: central vision, color vision, contrast sensitivity, scotopic function, photopic peripheral vision, mesopic peripheral vision, and photosensitivity. A total of 39 items were removed because of poor factor loading, low item information, poor person-ability differentiation, or high item-level interdependence. This novel questionnaire produces a reliable domain score for person ability that does not show significant test-retest variability across repeated administration.

conclusionsThe final PRO questionnaire, known as the Michigan Retinal Degeneration Questionnaire, is psychometrically validated and available for use in the evaluation of patients with inherited retinal degenerations.

Indexed as

Patient Reported Outcome MeasuresQuality of LifeActivities of Daily LivingAdolescentAdultAgedAged, 80 and overFemaleHumansIncidenceMaleMichiganMiddle AgedPsychometricsRetinal DegenerationRetrospective Studies

Identifiers

PMID32858027
PMCPMC7907279

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.